Alexion Pharmaceuticals
Alexion Pharmaceuticals sponsors 162 registered US clinical trials on ClinicalTrials.gov, 17 of them currently recruiting, and 93 completed. 45 of these trials are in Phase 3-4 (later-stage) and 90 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Paroxysmal Nocturnal Hemoglobinuria, with 5 trials.
Trial Pipeline
162 total, page 1 of 4
A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab
NCT07221838
ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With Acromegaly
NCT07037420
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy
NCT07218887
Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN)
NCT07157787
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
NCT07081646
Study of Ravulizumab in Pediatric Participants With Primary IgAN
NCT07024563
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
NCT06830798
Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation
NCT06744647
Study of Ultomiris® (Ravulizumab) Safety in Pregnancy
NCT06312644
PK, PD, Safety, and Efficacy Study of Gefurulimab in Pediatric Patients With AChR+ Generalized Myasthenia Gravis
NCT06607627
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
NCT06291376
Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies
NCT05966467
A Prospective Sub-Study of the Global Hypophosphatasia Registry
NCT05234567
Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
NCT05346354
Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)
NCT04202341
Lysosomal Acid Lipase (LAL) Deficiency Registry
NCT01633489
Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
NCT01522183
Assess Long-Term Safety of Danicopan Add-on Therapy in Participants With Paroxysmal Nocturnal Hemoglobinuria: Analysis of IPIG-Registry Data
NCT07413250
Long-term Safety of Danicopan: IPIG Registry-based Cohort Study
NCT07413679
Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP
NCT06079359
Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa
NCT06079372
Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
NCT06183931
Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa
NCT06079281
Evaluation of Pharmacokinetics, Pharmacodynamics, Efficacy, Safety, and Immunogenicity of Ravulizumab Administered Intravenously in Pediatric Participants With Generalized Myasthenia Gravis (gMG)
NCT05644561
Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism
NCT05778071
ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE
NCT05746559
Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis
NCT05556096
A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH
NCT05389449
A Study About the Natural History in Adults With BAG3 Dilated Cardiomyopathy (a Type of Heart Disease) (BAG3 DCM)
NCT05981092
Long-term Follow-up Study of Patients Who Received hLB-001 Gene Therapy
NCT05506254
Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant
NCT04543591
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)
NCT04512235
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)
NCT04504825
Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine
NCT06071442
Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Study of ALXN1820 in Adult Participants With Sickle Cell Disease
NCT05565092
Potential Drug Interaction Between ALXN2040 and Rosuvastatin
NCT05708573
Bioequivalence Between 180 mg and 60 mg ALXN2050 Tablets and Food Effect on ALXN2050 Pharmacokinetics
NCT05578846
Study of ALXN2050 in Adult Participants With Generalized Myasthenia Gravis
NCT05218096
Study of ALXN2050 in Participants With Hepatic Impairment
NCT05259085
Study of ALXN2050 in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)
NCT05097989
Drug-Drug Interaction (DDI) Study of ALXN2050 in Healthy Adult Participants
NCT05202145
Ravulizumab Versus Placebo in Adult Participants With Dermatomyositis
NCT04999020
Study of ALXN1850 in Participants With Hypophosphatasia (HPP)
NCT04980248
A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT05019521
Study of ALXN2050 in Healthy Adult Participants of Japanese Descent
NCT04952545
Study of ALXN2050 in Participants With Renal Impairment
NCT04623710
Ravulizumab in Thrombotic Microangiopathy Associated With a Trigger
NCT04743804
Trial of Andexanet in Patients Receiving an Oral FXa Inhibitor Who Require Urgent Surgery
NCT04233073
Drug Interaction Study of ALXN2050 With Fluconazole and Rifampin in Healthy Adult Participants
NCT04933682
Study to Assess the Effect of Food on a Single Dose of Acoramidis in Healthy Adult Participants
NCT04958135
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 43 |
| Phase 2 | 47 |
| Phase 3 | 42 |
| Phase 4 | 3 |
What the Pipeline for Alexion Pharmaceuticals Shows
According to the ClinicalTrials.gov registry, Alexion Pharmaceuticals is linked to 162 US clinical trials across every stage of research activity. Of those, 17 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 93 are already marked complete, representing roughly 57% of the total.
The phase mix for Alexion Pharmaceuticals reports 45 late-stage studies (Phase 3 and Phase 4 combined) and 90 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Alexion Pharmaceuticals is Paroxysmal Nocturnal Hemoglobinuria with 5 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.