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RECRUITING Phase 2

Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation

NCT06744647 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this study is to evaluate the efficacy of ALXN2030 compared with placebo on biopsy proven histologic resolution in participants with active or chronic active antibody-mediated rejection (AMR) at Week 52.

Interventions

  • DRUG Placebo
  • DRUG ALXN2030

Study Locations (20)

New York

  • Research Site — New York
  • Research Site — New York
  • Research Site — New York
  • Research Site — New York

California

  • Research Site — Los Angeles
  • Research Site — Orange

Michigan

  • Research Site — Ann Arbor
  • Research Site — Detroit

Texas

  • Research Site — Dallas
  • Research Site — Houston

Alabama

  • Research Site — Birmingham

Arizona

  • Research Site — Scottsdale

Florida

  • Research Site — Tampa

Georgia

  • Research Site — Atlanta

Trial Details

FieldValue
Enrollment Target 45 participants
Start Date 2025-03-07
Est. Completion 2028-11-07
Phase Phase 2

Sponsor

Alexion Pharmaceuticals

109 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06744647

The ClinicalTrials.gov registry entry for NCT06744647 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alexion Pharmaceuticals, which has 109 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Kidney Transplantation appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06744647 reports 20 study locations spanning 14 distinct geographic areas — top geographies include New York, California, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06744647 about?

NCT06744647 is a clinical study titled "Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation". The primary objective of this study is to evaluate the efficacy of ALXN2030 compared with placebo on biopsy proven histologic resolution in participants with active or chronic active antibody-mediated rejection (AMR) at Week 52.

What is the current status of trial NCT06744647?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 45 participants. The study started on 2025-03-07. Estimated completion is 2028-11-07.

What conditions does trial NCT06744647 study?

This clinical trial studies the following conditions: Kidney Transplantation, Antibody-Mediated Rejection, Biopsy-proven Histologic Scores, AMR. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06744647?

The interventions under investigation include: Placebo (DRUG), ALXN2030 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06744647?

This trial is sponsored by Alexion Pharmaceuticals, which has 109 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06744647 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial