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ClinicalTrials.gov 17 recruiting now official registry

Generalized Myasthenia Gravis clinical trials

Every US clinical trial registered for Generalized Myasthenia Gravis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

27 US clinical trials · 17 currently recruiting

The research picture

Generalized Myasthenia Gravis has 27 registered US clinical trials, 17 of them open to new participants right now — about 63% of the total.

17
recruiting participants now
63%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
7
top sponsor: argenx

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 500 participants

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

Alexion Pharmaceuticals

NCT04202341

RECRUITING Phase 3 264 participants

Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

NCT06463587

RECRUITING Phase 3 231 participants

Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

Immunovant Sciences

NCT07039916

RECRUITING Phase 3 180 participants

A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis (UPSTREAM MG)

Vor Biopharma

NCT06456580

RECRUITING Phase 3 180 participants

A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

Novartis Pharmaceuticals

NCT06744920

RECRUITING Phase 3 146 participants

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

Novartis Pharmaceuticals

NCT06517758

RECRUITING 70 participants

ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

argenx

NCT07294170

RECRUITING Phase 2 70 participants

ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod

argenx

NCT07284420

RECRUITING Phase 2 66 participants

KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

Kyverna Therapeutics

NCT06193889

RECRUITING NA 16 participants

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Myasthenia Gravis

University of Missouri-Columbia

NCT06064695

RECRUITING Phase 1 15 participants

Study to Assess Safety, Efficacy, and Cellular Kinetics of YTB323 in Generalized Myasthenia Gravis

Novartis Pharmaceuticals

NCT06704269

RECRUITING Phase 2 15 participants

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in Children With Generalized Myasthenia Gravis (gMG)

Amgen

NCT06987539

RECRUITING Phase 2 12 participants

Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis

argenx

NCT04833894

RECRUITING Phase 2 12 participants

A Study of Rozanolixizumab in Pediatric Study Participants With Moderate to Severe Generalized Myasthenia Gravis

UCB Biopharma SRL

NCT06149559

RECRUITING Phase 2 12 participants

A Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18 Years of Age With Generalized Myasthenia Gravis

argenx

NCT06392386

RECRUITING Phase 3 12 participants

PK, PD, Safety, and Efficacy Study of Gefurulimab in Pediatric Patients With AChR+ Generalized Myasthenia Gravis

Alexion Pharmaceuticals

NCT06607627

RECRUITING Phase 2 8 participants

A Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis

UCB Biopharma SRL

NCT06055959

ACTIVE NOT RECRUITING Phase 3 288 participants

A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

Regeneron Pharmaceuticals

NCT05070858

ACTIVE NOT RECRUITING Phase 3 261 participants

Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis

Alexion Pharmaceuticals

NCT05556096

ACTIVE NOT RECRUITING Phase 3 240 participants

Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis

Immunovant Sciences

NCT05403541

ACTIVE NOT RECRUITING Phase 3 200 participants

Open-Label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis

UCB Biopharma SRL

NCT04225871

ACTIVE NOT RECRUITING Phase 3 119 participants

A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis

argenx

NCT06298552

ACTIVE NOT RECRUITING Phase 3 12 participants

Evaluation of Pharmacokinetics, Pharmacodynamics, Efficacy, Safety, and Immunogenicity of Ravulizumab Administered Intravenously in Pediatric Participants With Generalized Myasthenia Gravis (gMG)

Alexion Pharmaceuticals

NCT05644561

COMPLETED Phase 3 200 participants

A Study to Test Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis

UCB Biopharma SRL

NCT03971422

COMPLETED Phase 3 167 participants

An Efficacy and Safety Study of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness

argenx

NCT03669588

COMPLETED Phase 3 69 participants

An Open-label Study to Investigate the Clinical Efficacy of Different Dosing Regimens of Efgartigimod IV in Patients With Generalized Myasthenia Gravis

argenx

NCT04980495

COMPLETED Phase 2 45 participants

Safety and Efficacy Study of RA101495 in Subjects With Generalized Myasthenia Gravis

Ra Pharmaceuticals

NCT03315130

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 8
Phase 3 15

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Generalized Myasthenia Gravis Trial Landscape

ClinicalTrials.gov lists 27 US studies indexed under Generalized Myasthenia Gravis, and 17 of those are currently open to recruitment — roughly 63% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Generalized Myasthenia Gravis shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Generalized Myasthenia Gravis is led by argenx with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 27 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Generalized Myasthenia Gravis?

PlainTrial tracks 27 US clinical trials for Generalized Myasthenia Gravis, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Generalized Myasthenia Gravis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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