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NCT05746559 · ClinicalTrials.gov registry record · Phase 3
ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE
A Phase 3 study of Chronic Kidney Disease and Cardiac Disease, sponsored by Alexion Pharmaceuticals.
- Active
- Registry status
- Phase 3
- Development phase
- 736
- Enrollment target
- 20
- Study locations
NCT05746559: Active Phase 3 study of Chronic Kidney Disease and Cardiac Disease, sponsored by Alexion Pharmaceuticals.
NCT05746559 is a Phase 3 study of Chronic Kidney Disease and Cardiac Disease that is active but no longer recruiting, run by Alexion Pharmaceuticals. The registered enrollment target is 736 participants, below the 3,200-participant average among 101 other Chronic Kidney Disease trials with a reported enrollment target (77% lower). The trial reports 20 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05746559, a Phase 3 study of Chronic Kidney Disease and Cardiac Disease, is active but no longer recruiting, sponsored by Alexion Pharmaceuticals.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 736 participants
- Enrollment target
- 20
- Study locations
Study Summary
The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent cardiac surgery with CPB.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Ravulizumab
Study Locations (20)
California
- Research Site - Orange
- Research Site - San Francisco
- Research Site - San Francisco
- Research Site - Stanford
Massachusetts
- Research Site - Boston
- Research Site - Springfield
Missouri
- Research Site - Kansas City
- Research Site - St Louis
New York
- Research Site - Rochester
- Research Site - Valhalla
Arizona
- Research Site - Tucson
Colorado
- Research Site - Aurora
Florida
- Research Site - Weston
Georgia
- Research Site - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 736 participants |
| Start Date | 2023-04-06 |
| Est. Completion | 2027-02-17 |
| Phase | Phase 3 |
What the registry record for NCT05746559 still lists
NCT05746559 is an interventional study that assigns participants to a tested intervention. The registered 736 participants enrollment target is mid-sized for trials with a published cap, below the 3,200-participant average among 101 other Chronic Kidney Disease trials with a reported enrollment target (77% lower).
The record links to 4 conditions, with Chronic Kidney Disease appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05746559 names 20 study sites across 14 states, led by California, Massachusetts, Missouri.
Frequently Asked Questions
What is clinical trial NCT05746559 about?
NCT05746559 is a clinical study titled "ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE". The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent cardiac surgery with CPB.
What is the current status of trial NCT05746559?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 736 participants. The study started on 2023-04-06. Estimated completion is 2027-02-17.
What conditions does trial NCT05746559 study?
This clinical trial studies the following conditions: Chronic Kidney Disease, Cardiac Disease, Cardiopulmonary Bypass, CKD.
What interventions are being tested in trial NCT05746559?
The interventions under investigation include: Placebo (DRUG), Ravulizumab (DRUG).
Who is sponsoring clinical trial NCT05746559?
This trial is sponsored by Alexion Pharmaceuticals, which has 162 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05746559 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Kidney Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05746559's enrollment target sits among peer trials
736 21st of 101 higher than 81 of 101 other Chronic Kidney Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Kidney Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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