Agios Pharmaceuticals

44 total trials 3 currently recruiting 31 completed

Agios Pharmaceuticals sponsors 44 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 31 completed. 7 of these trials are in Phase 3-4 (later-stage) and 33 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy Volunteers, with 3 trials.

Trial Pipeline

44 total, page 1 of 1

RECRUITING Phase 1

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-181 in Subjects With Phenylketonuria

NCT07241234

RECRUITING Phase 1

A Study to Determine the Safety and Tolerability of AG-236 and How it is Absorbed, Broken Down, and Eliminated From the Body in Healthy Participants

NCT07075640

RECRUITING Phase 2

A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)

NCT06924970

ACTIVE NOT RECRUITING Phase 2

A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)

NCT05490446

ACTIVE NOT RECRUITING Phase 3

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period

NCT05144256

ACTIVE NOT RECRUITING Phase 3

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period

NCT05175105

ACTIVE NOT RECRUITING Phase 2

A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)

NCT05031780

ACTIVE NOT RECRUITING Phase 3

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)

NCT04770753

ACTIVE NOT RECRUITING Phase 3

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

NCT04770779

ACTIVE NOT RECRUITING Phase 2

A Study to Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AG-348 in Adult Participants With Non-transfusion-dependent Thalassemia

NCT03692052

ACTIVE NOT RECRUITING

Pyruvate Kinase Deficiency Global Longitudinal Registry

NCT03481738

COMPLETED Phase 1

A Study to Determine How Tebapivat is Absorbed, Broken Down, and Removed From the Body and the Extent to Which Tebapivat is Made Available in the Body in Healthy Participants

NCT06745271

COMPLETED Phase 1

Study of How Mitapivat Affects Midazolam Blood Levels in Healthy Participants

NCT06648824

COMPLETED Phase 1

Single and Multiple Ascending Dose Study and Food Effect Study for AG181

NCT06286033

COMPLETED Phase 1

A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function

NCT05610657

COMPLETED

Pyruvate Kinase Deficiency Global Longitudinal Registry Substudy of Protocol AG348-C-008

NCT04995315

TERMINATED

Pyruvate Kinase (PK) Deficiency Global Longitudinal Registry: Patient-Reported Outcomes (PRO)

NCT04964323

COMPLETED Phase 1

A Study to Compare the Pharmacokinetics and Safety of Mitapivat 100 mg Tablet Formulation With Mitapivat 2 × 50 mg Tablet Formulation in Healthy Adult Participants

NCT04696393

COMPLETED Phase 1

A Study to Assess the Relative Bioavailability and Effect of Food on the Coated Granule Formulation of Mitapivat in Healthy Participants

NCT04565678

COMPLETED Phase 1

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers and in Participants With Sickle Cell Disease

NCT04536792

COMPLETED Phase 1

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Mitapivat (AG-348) in Healthy Adult Participants

NCT04472832

COMPLETED Phase 1

A Study to Evaluate AG-881 in Healthy Japanese and Non-Asian Participants

NCT04145128

COMPLETED Phase 1

A Study to Compare the Relative Bioavailability of Two AG-881 Formulations and Evaluate the Effect of Food and Omeprazole on the Pharmacokinetics of AG-881

NCT04128787

COMPLETED Phase 1

A Study to Evaluate the Effect of AG-881 on the Pharmacokinetics of a Single Dose of Lamotrigine in Healthy Adults

NCT04015687

COMPLETED Phase 1

Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants

NCT03991312

TERMINATED Phase 1

A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma

NCT03834584

COMPLETED Phase 1

A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881

NCT03960502

COMPLETED Phase 3

Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007

NCT03853798

COMPLETED Phase 3

A Study to Evaluate Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

NCT03548220

COMPLETED Phase 3

A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

NCT03559699

COMPLETED Phase 1

A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-348 and Concomitant Single Intravenous Microdose of [13C6]AG-348

NCT03703505

COMPLETED

Pre-Screening Study to Identify MTAP Loss in Advanced Solid Tumors or Lymphoma

NCT03361358

COMPLETED Phase 1

Study to Evaluate the Relative Bioavailability and Safety of the AG-348 Tablet and Capsule Formulations in Healthy Adults

NCT03397329

COMPLETED Phase 1

A Study of AG-120 (Ivosidenib) in Subjects With Mild or Moderate Hepatic Impairment or Normal Hepatic Function

NCT03282513

COMPLETED Phase 1

Study to Evaluate the Pharmacokinetics, Safety, and QTc Effect of AG-348 in Healthy Subjects of Japanese Origin and Non-Asian Origin

NCT03250598

COMPLETED Phase 1

Japanese Bridging Study of Ivosidenib (AG-120) in Healthy Subjects

NCT03071770

COMPLETED Phase 1

Drug-Drug Interaction Study of AG120 in Healthy Subjects

NCT02831972

COMPLETED Phase 1

Food Effect Study of AG120 in Healthy Subjects

NCT02579707

COMPLETED Phase 1

Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation

NCT02492737

COMPLETED Phase 2

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

NCT02476916

COMPLETED Phase 1

Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-AG-120

NCT02489513

COMPLETED Phase 1

Food Effect Study of AG-221 in Healthy Male Subjects

NCT02218346

COMPLETED Phase 1

A Phase I Study of AG-348 in Healthy Volunteers

NCT02149966

COMPLETED Phase 1

A Phase I Study of AG-348 in Healthy Volunteers

NCT02108106

What the Pipeline for Agios Pharmaceuticals Shows

According to the ClinicalTrials.gov registry, Agios Pharmaceuticals is linked to 44 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 7% of the sponsor's indexed portfolio, and 31 are already marked complete, representing roughly 70% of the total.

The phase mix for Agios Pharmaceuticals reports 7 late-stage studies (Phase 3 and Phase 4 combined) and 33 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Agios Pharmaceuticals is Healthy Volunteers with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.