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RECRUITING Phase 2

A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)

NCT06924970 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to compare the effect of tebapivat versus placebo on anemia and to detect a dose-response for hemoglobin (Hb) response in participants with SCD.

Conditions Studied

Interventions

  • DRUG Tebapivat
  • DRUG Tebapivat Matched Placebo

Study Locations (20)

District of Columbia

  • Children's National Hospital — Washington D.C.
  • MedStar Washington Hospital Center — Washington D.C.

Michigan

  • Henry Ford Health System — Detroit
  • Children's Hospital of Michigan — Detroit

New York

  • Icahn School of Medicine at Mt. Sinai — New York
  • Montefiore Medical Center — The Bronx

Pennsylvania

  • Thomas Jefferson University Hospital — Philadelphia
  • University of Pittsburgh Medical Center — Pittsburgh

Wallonne

  • CHR de la Citadelle — Liège
  • Clinique CHC MontLégia — Liège

Colorado

  • UCHealth at University of Colorado Anschutz Medical Campus — Aurora

Connecticut

  • UConn Health — Farmington

Georgia

  • Emory-Children's Center/ Children's Healthcare of Atlanta: Arthur M. Blank Hospital — Atlanta

Trial Details

FieldValue
Enrollment Target 56 participants
Start Date 2025-05-01
Est. Completion 2027-05
Phase Phase 2

Sponsor

Agios Pharmaceuticals

15 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06924970

The ClinicalTrials.gov registry entry for NCT06924970 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 56 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Agios Pharmaceuticals, which has 15 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Sickle Cell Disease appearing as the primary indexed condition, and to 2 interventions — of which Tebapivat is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06924970 reports 20 study locations spanning 15 distinct geographic areas — top geographies include District of Columbia, Michigan, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06924970 about?

NCT06924970 is a clinical study titled "A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)". The main purpose of this study is to compare the effect of tebapivat versus placebo on anemia and to detect a dose-response for hemoglobin (Hb) response in participants with SCD.

What is the current status of trial NCT06924970?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 56 participants. The study started on 2025-05-01. Estimated completion is 2027-05.

What conditions does trial NCT06924970 study?

This clinical trial studies the following conditions: Sickle Cell Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06924970?

The interventions under investigation include: Tebapivat (DRUG), Tebapivat Matched Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06924970?

This trial is sponsored by Agios Pharmaceuticals, which has 15 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06924970 being conducted?

This trial has 20 study locations across Colorado, Connecticut, District of Columbia, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial