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NCT02492737 · ClinicalTrials.gov registry record · Phase 1

Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation

A Phase 1 study, sponsored by Agios Pharmaceuticals.

Completed
Registry status
Phase 1
Development phase
46
Enrollment target

NCT02492737: Completed Phase 1 study, sponsored by Agios Pharmaceuticals.

NCT02492737 is a Phase 1 study that has completed, run by Agios Pharmaceuticals. The registered enrollment target is 46 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (23% lower). According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT02492737, a Phase 1 study, has completed, sponsored by Agios Pharmaceuticals.

COMPLETED
Registry status
Phase 1
Development phase
46 participants
Enrollment target

Study Summary

The purpose of this Phase I, multicenter study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-881 in advanced hematologic malignancies that harbor an IDH1 and/or IDH2 mutation

Interventions

  • DRUG AG881

Trial Details

FieldValue
Enrollment Target 46 participants
Start Date 2015-08-07
Est. Completion 2018-03-21
Phase Phase 1
Agios Pharmaceuticals

44 total trials

What the finished NCT02492737 record still lists

NCT02492737 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 46 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (23% lower).

The record links to 0 conditions, and to 1 intervention - of which AG881 is the first listed.

NCT02492737 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT02492737 about?

NCT02492737 is a clinical study titled "Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation". The purpose of this Phase I, multicenter study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-881 in advanced hematologic malignancies that harbor an IDH1 and/or IDH2 mutation

What is the current status of trial NCT02492737?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 46 participants. The study started on 2015-08-07. Estimated completion is 2018-03-21.

What interventions are being tested in trial NCT02492737?

The interventions under investigation include: AG881 (DRUG).

Who is sponsoring clinical trial NCT02492737?

This trial is sponsored by Agios Pharmaceuticals, which has 44 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT02492737's enrollment target sits among peer trials

46 1058th of 2000 higher than 935 of 2,000 other Phase 1 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT02492737, the US trial registry maintained by the National Library of Medicine. NCT02492737 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.