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ClinicalTrials.gov 23 recruiting now official registry

Type 1 Diabetes Mellitus clinical trials

23 of 106 indexed Type 1 Diabetes Mellitus trials are currently recruiting.

106 US clinical trials · 23 currently recruiting

Type 1 Diabetes Mellitus is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 35 in Phase 1-2 (earlier-stage). The most active sponsor is University of Virginia, running 8 of these trials.

The research picture

Type 1 Diabetes Mellitus has 106 registered US clinical trials, 23 of them open to new participants right now, about 22% of the total.

23
recruiting participants now
22%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
8
top sponsor: University of Virginia
Phase 119Phase 216Phase 314Phase 45

Active & Recent Trials

106 total, page 2 of 3

COMPLETED NA 132 participants

CloudConnect: Predictive And Retrospective Clinical Decision Support For Chronic Disease Management

University of Virginia

NCT03676465

COMPLETED Phase 3 125 participants

6-month Comparison of Morning Lantus Versus Neutral Protamine Hagedorn Insulin in Young Children With Type 1 Diabetes

Sanofi

NCT00993473

COMPLETED NA 120 participants

Initiation of Continuous Glucose Monitoring at Diagnosis of Type 1 Diabetes

Korey Hood

NCT02734667

COMPLETED 120 participants

Efficacy of Continuous Glucose Monitoring in Subjects With Type 1 Diabetes Mellitus on Multiple Daily Injections (MDI) or Continuous Subcutaneous Insulin Infusion (CSII) Therapy

DexCom

NCT01104142

COMPLETED NA 116 participants

Use of Continuous Glucose Sensors by Adolescents With Inadequate Diabetic Control

Nemours Children's Clinic

NCT00945659

COMPLETED NA 99 participants

Nutritional Intervention to Prevent Diabetes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00333554

COMPLETED Phase 1 86 participants

A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A

Hanmi Pharmaceutical Company Limited

NCT01724814

COMPLETED NA 83 participants

New Glucose Sensor Pediatric

Medtronic Diabetes

NCT01161043

COMPLETED 64 participants

Gene Expression Profiling in Type 1 Diabetes

Children's Mercy Hospital Kansas City

NCT00330954

COMPLETED Phase 2 63 participants

PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)

Mesoblast

NCT00690066

COMPLETED Phase 2 60 participants

Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus

Brigham and Women's Hospital

NCT00762671

COMPLETED NA 57 participants

Effect of Diabetes Mellitus on Cholesterol Metabolism

Medical College of Wisconsin

NCT00879710

COMPLETED NA 51 participants

A Cognitive Behavioral Therapy (CBT) Intervention to Reduce Fear of Hypoglycemia in Type 1 Diabetes

University of Illinois at Chicago

NCT03549104

COMPLETED NA 50 participants

The VRIF Trial: Hypoglycemia Reduction With Automated-Insulin Delivery System

University of Virginia

NCT03674281

COMPLETED 50 participants

Sleep and Glucose Regulation in Youth With Type 1 Diabetes Mellitus

University of Arizona

NCT00848822

COMPLETED Phase 1 50 participants

Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function

University of Colorado, Denver

NCT03618420

COMPLETED NA 50 participants

Assess the Efficacy of the Low Glucose Suspend (LGS) Feature in the MiniMed Paradigm® X54 System

Medtronic Diabetes

NCT01148862

COMPLETED Phase 3 48 participants

Islet Transplantation in Type 1 Diabetes

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00434811

COMPLETED 41 participants

Diabetic Kidney Alarm (DKA) Study

University of Colorado, Denver

NCT03128229

COMPLETED Phase 1 37 participants

TAK-329 Glucose Clamp Study

Takeda

NCT01311076

COMPLETED 37 participants

Glycemic Profiles And Insulin Delivery Across The Menstrual Cycle In Women With Type 1 Diabetes

University of Virginia

NCT04665999

COMPLETED NA 37 participants

Medtronic Minimed Overnight Closed-Loop System

Bruce A. Buckingham

NCT01881009

COMPLETED Phase 2 36 participants

Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus

Lexicon Pharmaceuticals

NCT01742208

COMPLETED Early Phase 1 36 participants

Crossover Feasibility Study of Portable AP Device With Zone-MPC and HMS and Adapted I:C and Basal Insulin

Sansum Diabetes Research Institute

NCT01929798

COMPLETED NA 35 participants

Tissue-Specific Metabolic Reprogramming in Diabetic Complications

University of Michigan

NCT01823406

COMPLETED Phase 2 32 participants

Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes

University of Alabama at Birmingham

NCT02372253

COMPLETED Phase 3 32 participants

At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation

Sansum Diabetes Research Institute

NCT02705053

COMPLETED NA 32 participants

Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp

Daniel Chernavvsky, MD, CRC

NCT02604524

COMPLETED NA 31 participants

Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery

University of Virginia

NCT04784637

COMPLETED Phase 1 30 participants

Hyaluronidase Effect on Infusion Set Life

Stanford University

NCT02199028

COMPLETED NA 30 participants

Intervention Groups for Adolescents With Type 1 Diabetes Mellitus

Children's Hospital and Health System Foundation, Wisconsin

NCT00622271

COMPLETED 30 participants

Neuropsychological and Neuroanatomical Studies of Young Children With and Without Type 1 Diabetes Mellitus

Stanford University

NCT00449891

COMPLETED Phase 3 27 participants

Pediatric Diabetics Type 1 Using InsuPatch

Insuline Medical

NCT01368978

COMPLETED Phase 4 26 participants

Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon

Massachusetts General Hospital

NCT02516150

COMPLETED Phase 1 24 participants

Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab

REMD Biotherapeutics

NCT06272695

COMPLETED NA 24 participants

Pregnancy Intervention With a Closed-Loop System (PICLS) Study

University of Colorado, Denver

NCT03774186

COMPLETED Phase 3 24 participants

Efficacy of Islet After Kidney Transplantation

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00468117

COMPLETED NA 22 participants

Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin

University of Virginia

NCT03804983

COMPLETED NA 20 participants

Outpatient Control-to-Range: System and Monitoring Testing

University of Virginia

NCT01578980

COMPLETED 20 participants

The Multi-Sensor Distance Accuracy Study

Oregon Health and Science University

NCT02241993

COMPLETED Phase 3 20 participants

To Evaluate the Effect on Post-prandial Glycemia Safety, and Tolerability of Viaject 7 vs. Lispro Insulin During Subcutaneous Insulin Pump Therapy

Biodel

NCT01110746

COMPLETED Phase 1 20 participants

A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Doses of SAR438544 in Comparison to Placebo and Glucagon in Healthy Subjects and Type 1 Diabetes Mellitus Patients

Sanofi

NCT02625636

COMPLETED NA 19 participants

Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus

University of Texas Southwestern Medical Center

NCT03655067

COMPLETED Phase 4 18 participants

Detemir: Role in Type 1 Diabetes

Montefiore Medical Center

NCT00564395

COMPLETED Phase 4 16 participants

The Effect of Insulin Glulisine Compared With Insulin Aspart on Breakfast Post Prandial Glucose Levels in Prepubertal Children

Corewell Health West

NCT00913497

COMPLETED Phase 2 16 participants

A Clinical Study of the Performance of a Glucose Blinding Protein-Based Continuous Glucose Monitor (GBP CGM)

University of Virginia

NCT01469715

COMPLETED Phase 1 16 participants

T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs

University of California, San Francisco

NCT01210664

COMPLETED Phase 1 16 participants

T1DM Immunotherapy Using Polyclonal Tregs + IL-2

Jeffrey Bluestone

NCT02772679

COMPLETED 15 participants

Development of an Advisory System for Glycemic Control During the Menstrual Cycle in Patient With Type 1 Diabetes

University of Virginia

NCT01653210

COMPLETED Phase 1 15 participants

A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus

Brigham and Women's Hospital

NCT01421355

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 16
Phase 3 14
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 1 Diabetes Mellitus Trial Landscape

106 indexed Type 1 Diabetes Mellitus studies · 23 recruiting (22%).

Phase mix: 19 late (III/IV) vs 35 early (I/II).

Top sponsor: University of Virginia (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 1 Diabetes Mellitus?

PlainTrial tracks 106 US clinical trials for Type 1 Diabetes Mellitus, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 1 Diabetes Mellitus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.