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Type 1 Diabetes Mellitus clinical trials
23 of 106 indexed Type 1 Diabetes Mellitus trials are currently recruiting.
106 US clinical trials · 23 currently recruiting
Type 1 Diabetes Mellitus is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 35 in Phase 1-2 (earlier-stage). The most active sponsor is University of Virginia, running 8 of these trials.
The research picture
Type 1 Diabetes Mellitus has 106 registered US clinical trials, 23 of them open to new participants right now, about 22% of the total.
- 23
- recruiting participants now
- 22%
- of trials open to enrollment
- 19
- in Phase 3–4 (later-stage)
- 8
- top sponsor: University of Virginia
Active & Recent Trials
106 total, page 2 of 3
CloudConnect: Predictive And Retrospective Clinical Decision Support For Chronic Disease Management
University of Virginia
NCT03676465
6-month Comparison of Morning Lantus Versus Neutral Protamine Hagedorn Insulin in Young Children With Type 1 Diabetes
Sanofi
NCT00993473
Initiation of Continuous Glucose Monitoring at Diagnosis of Type 1 Diabetes
Korey Hood
NCT02734667
Efficacy of Continuous Glucose Monitoring in Subjects With Type 1 Diabetes Mellitus on Multiple Daily Injections (MDI) or Continuous Subcutaneous Insulin Infusion (CSII) Therapy
DexCom
NCT01104142
Use of Continuous Glucose Sensors by Adolescents With Inadequate Diabetic Control
Nemours Children's Clinic
NCT00945659
Nutritional Intervention to Prevent Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00333554
A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A
Hanmi Pharmaceutical Company Limited
NCT01724814
New Glucose Sensor Pediatric
Medtronic Diabetes
NCT01161043
Gene Expression Profiling in Type 1 Diabetes
Children's Mercy Hospital Kansas City
NCT00330954
PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
Mesoblast
NCT00690066
Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus
Brigham and Women's Hospital
NCT00762671
Effect of Diabetes Mellitus on Cholesterol Metabolism
Medical College of Wisconsin
NCT00879710
A Cognitive Behavioral Therapy (CBT) Intervention to Reduce Fear of Hypoglycemia in Type 1 Diabetes
University of Illinois at Chicago
NCT03549104
The VRIF Trial: Hypoglycemia Reduction With Automated-Insulin Delivery System
University of Virginia
NCT03674281
Sleep and Glucose Regulation in Youth With Type 1 Diabetes Mellitus
University of Arizona
NCT00848822
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
University of Colorado, Denver
NCT03618420
Assess the Efficacy of the Low Glucose Suspend (LGS) Feature in the MiniMed Paradigm® X54 System
Medtronic Diabetes
NCT01148862
Islet Transplantation in Type 1 Diabetes
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00434811
Diabetic Kidney Alarm (DKA) Study
University of Colorado, Denver
NCT03128229
TAK-329 Glucose Clamp Study
Takeda
NCT01311076
Glycemic Profiles And Insulin Delivery Across The Menstrual Cycle In Women With Type 1 Diabetes
University of Virginia
NCT04665999
Medtronic Minimed Overnight Closed-Loop System
Bruce A. Buckingham
NCT01881009
Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus
Lexicon Pharmaceuticals
NCT01742208
Crossover Feasibility Study of Portable AP Device With Zone-MPC and HMS and Adapted I:C and Basal Insulin
Sansum Diabetes Research Institute
NCT01929798
Tissue-Specific Metabolic Reprogramming in Diabetic Complications
University of Michigan
NCT01823406
Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes
University of Alabama at Birmingham
NCT02372253
At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation
Sansum Diabetes Research Institute
NCT02705053
Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp
Daniel Chernavvsky, MD, CRC
NCT02604524
Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
University of Virginia
NCT04784637
Hyaluronidase Effect on Infusion Set Life
Stanford University
NCT02199028
Intervention Groups for Adolescents With Type 1 Diabetes Mellitus
Children's Hospital and Health System Foundation, Wisconsin
NCT00622271
Neuropsychological and Neuroanatomical Studies of Young Children With and Without Type 1 Diabetes Mellitus
Stanford University
NCT00449891
Pediatric Diabetics Type 1 Using InsuPatch
Insuline Medical
NCT01368978
Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon
Massachusetts General Hospital
NCT02516150
Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab
REMD Biotherapeutics
NCT06272695
Pregnancy Intervention With a Closed-Loop System (PICLS) Study
University of Colorado, Denver
NCT03774186
Efficacy of Islet After Kidney Transplantation
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00468117
Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin
University of Virginia
NCT03804983
Outpatient Control-to-Range: System and Monitoring Testing
University of Virginia
NCT01578980
The Multi-Sensor Distance Accuracy Study
Oregon Health and Science University
NCT02241993
To Evaluate the Effect on Post-prandial Glycemia Safety, and Tolerability of Viaject 7 vs. Lispro Insulin During Subcutaneous Insulin Pump Therapy
Biodel
NCT01110746
A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Doses of SAR438544 in Comparison to Placebo and Glucagon in Healthy Subjects and Type 1 Diabetes Mellitus Patients
Sanofi
NCT02625636
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
University of Texas Southwestern Medical Center
NCT03655067
Detemir: Role in Type 1 Diabetes
Montefiore Medical Center
NCT00564395
The Effect of Insulin Glulisine Compared With Insulin Aspart on Breakfast Post Prandial Glucose Levels in Prepubertal Children
Corewell Health West
NCT00913497
A Clinical Study of the Performance of a Glucose Blinding Protein-Based Continuous Glucose Monitor (GBP CGM)
University of Virginia
NCT01469715
T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs
University of California, San Francisco
NCT01210664
T1DM Immunotherapy Using Polyclonal Tregs + IL-2
Jeffrey Bluestone
NCT02772679
Development of an Advisory System for Glycemic Control During the Menstrual Cycle in Patient With Type 1 Diabetes
University of Virginia
NCT01653210
A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus
Brigham and Women's Hospital
NCT01421355
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 1 Diabetes Mellitus Trial Landscape
106 indexed Type 1 Diabetes Mellitus studies · 23 recruiting (22%).
Phase mix: 19 late (III/IV) vs 35 early (I/II).
Top sponsor: University of Virginia (8 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 1 Diabetes Mellitus?
PlainTrial tracks 106 US clinical trials for Type 1 Diabetes Mellitus, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 1 Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.