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Systemic Lupus Erythematosus clinical trials
43 of 100 indexed Systemic Lupus Erythematosus trials are currently recruiting.
100 US clinical trials · 43 currently recruiting
Systemic Lupus Erythematosus is the subject of 100 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 54 in Phase 1-2 (earlier-stage). The most active sponsor is Bristol-Myers Squibb, running 6 of these trials.
The research picture
Systemic Lupus Erythematosus has 100 registered US clinical trials, 43 of them open to new participants right now, about 43% of the total.
- 43
- recruiting participants now
- 43%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 6
- top sponsor: Bristol-Myers Squibb
Active & Recent Trials
100 total, page 1 of 2
Rheumatology Patient Registry and Biorepository
Yale University
NCT04402086
Study of Systemic Lupus Erythematosus
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00001372
Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus
AbbVie
NCT05843643
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University
NCT03276923
Duke Lupus Registry
Duke University
NCT00512694
CorEvitas Systemic Lupus Erythematosus (SLE) Drug Safety and Effectiveness Registry
CorEvitas
NCT06804057
Systemic Lupus Erythematosus in Gullah Health
Medical University of South Carolina
NCT00756769
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)
Hospital for Special Surgery, New York
NCT00198068
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
Novartis Pharmaceuticals
NCT06133972
Intervention to Improve Communication and Medication Adherence in Lupus
Duke University
NCT06458075
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
UCB Biopharma SRL
NCT06617325
Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users
AstraZeneca
NCT06659029
A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)
GlaxoSmithKline
NCT06411249
Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease
NYU Langone Health
NCT05799378
Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine
State University of New York - Upstate Medical University
NCT00775476
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
NCT05869955
Safety of the Herpes Zoster Subunit Vaccine in Lupus
NYU Langone Health
NCT05559671
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Amgen
NCT06570798
Creating Health Course Study for People With Rheumatological Conditions
Terry L. Wahls
NCT07180537
A Study of Obexelimab in Patients With Systemic Lupus Erythematosus
Zenas BioPharma (USA)
NCT06559163
A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Pharmacodynamics, and Efficacy of P-CD19CD20-ALLO1 in Participants With Severe, Treatment-refractory Systemic Lupus Erythematosus (SLE)
Genentech
NCT06984341
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
GlaxoSmithKline
NCT06576271
Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus Erythematosus
Sanofi
NCT05039840
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
AstraZeneca
NCT05835310
Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
Children's National Research Institute
NCT04833465
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
AstraZeneca
NCT06916806
Safety and Efficacy of ONT01 in Lupus
Hospital for Special Surgery, New York
NCT07107659
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
AstraZeneca
NCT07201558
Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
M.D. Anderson Cancer Center
NCT06434363
The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT05440422
Electroencephalogram Recording in Patients With Systemic Lupus Erythematosus
Northwell Health
NCT06378736
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE) and Sjogren's Disease (SjD)
AbbVie
NCT06977724
A Phase 1b Study of Budoprutug in Systemic Lupus Erythematosus (SLE)
Climb Bio
NCT07011043
Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
IRIS Research and Development
NCT06581562
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
Cabaletta Bio
NCT06121297
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evaluating the Efficacy and Safety of VENT-03 in Adult Participants With Active Cutaneous Lupus Erythematosus With or Without Systemic Lupus Erythematosus
Ventus Therapeutics U.S.
NCT07260877
Alnuctamab for Refractory SLE (LATTE Study)
Icahn School of Medicine at Mount Sinai
NCT07219563
Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
Stephan Grupp MD PhD
NCT05029336
BAFF CAR-T Cells (LMY-920) for Systemic Lupus Erythematosus
Luminary Therapeutics
NCT06340750
Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users
AstraZeneca
NCT06594068
REACT-01: Reversing Autoimmunity Through Cell Therapy
Seattle Children's Hospital
NCT06465147
UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients
LiveKidney.Bio
NCT06737380
A Study of NKX019, a CD19 CAR NK Cell Therapy, in Subjects With Systemic Lupus Erythematosus
Columbia University
NCT06518668
A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
Bristol-Myers Squibb
NCT05617677
A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus
Bristol-Myers Squibb
NCT05620407
Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1)
Novartis Pharmaceuticals
NCT05639114
The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
NCT05540327
Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus
AstraZeneca
NCT04877691
Peer Approaches to Lupus Self-management
Medical University of South Carolina
NCT03734055
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
Hoffmann-La Roche
NCT04963296
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 30 |
| Phase 2 | 24 |
| Phase 3 | 15 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Systemic Lupus Erythematosus Trial Landscape
100 indexed Systemic Lupus Erythematosus studies · 43 recruiting (43%).
Phase mix: 21 late (III/IV) vs 54 early (I/II).
Top sponsor: Bristol-Myers Squibb (6 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Systemic Lupus Erythematosus?
PlainTrial tracks 100 US clinical trials for Systemic Lupus Erythematosus, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Systemic Lupus Erythematosus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.