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Septic Shock clinical trials
Every US clinical trial registered for Septic Shock — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
25 US clinical trials · 9 currently recruiting
The research picture
Septic Shock has 25 registered US clinical trials, 9 of them open to new participants right now — about 36% of the total.
- 9
- recruiting participants now
- 36%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Spectral Diagnostics (US)
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Children's Hospital of Philadelphia
NCT05975671
Assessment for Implementation Methods in Sepsis
Rhode Island Hospital
NCT05491941
Stress Hydrocortisone In Pediatric Septic Shock
Jerry Zimmerman
NCT03401398
Early Versus Late Adjunctive Vasopressin in Septic Shock
The Cleveland Clinic
NCT06709573
Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock
Kingman Regional Medical Center
NCT06122987
A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)
Vivacelle Bio
NCT06072430
Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis
University of Oklahoma
NCT03992378
Early Angiotensin II in the Emergency Department
Brett A Faine
NCT06693726
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
University of Pennsylvania
NCT04855786
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
Henry Ford Health System
NCT05296590
Vasopressin for Septic Shock Pragmatic Trial
Intermountain Health Care
NCT06217562
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Spectral Diagnostics (US)
NCT03901807
Blood Purification for the Treatment of Pathogen Associated Shock
ExThera Medical Corporation
NCT05011656
Predictive algoRithm for EValuation and Intervention in SEpsis
Dascena
NCT03235193
Evaluation of the Heparin Binding Protein Levels in Sepsis
Christiana Care Health Services
NCT02533011
Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock
Methodist Health System
NCT04153578
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock
Spectral Diagnostics (US)
NCT01046669
Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock
University of British Columbia
NCT01867905
Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation
National Institute of General Medical Sciences (NIGMS)
NCT00372502
Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population
Abionic
NCT04409561
HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients
University of Tennessee Medical Center
NCT03710187
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
National Center for Research Resources (NCRR)
NCT00005890
Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock
University of New Mexi
NCT05824767
Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
George Washington University
NCT01393782
Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock
The Cleveland Clinic
NCT03014063
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 3 | 2 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Septic Shock Trial Landscape
ClinicalTrials.gov lists 25 US studies indexed under Septic Shock, and 9 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Septic Shock shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Septic Shock is led by Spectral Diagnostics (US) with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Septic Shock?
PlainTrial tracks 25 US clinical trials for Septic Shock, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Septic Shock?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.