Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Septic Shock: later-stage trial registry
9 of 25 indexed Septic Shock trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #652 of 28,707 conditions by registered trial count.
25 US clinical trials · 9 currently recruiting · #652 of 28,707 conditions by registered trial count
Septic Shock: 25 US clinical trials tracked, 9 recruiting.
Septic Shock is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Spectral Diagnostics (US), running 2 of these trials.
Enrollment posture brief
Registry condition septic-shock
OPEN 9 | RECR 36% | LATE 7 | EARLY 2 | RANK #652 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Cannabis (36% recruiting · 25 trials)
Septic Shock lists 9 open slots (36% of 25 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Septic Shock on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Septic Shock is recruiting below its size-band peers.
9 of 25 indexed trials (36%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Septic Shock trials is spread across many organizations.
Spectral Diagnostics (US) accounts for 2 of 25 trials (8%). 23 distinct sponsors appear on at least one study for this condition label.
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Typical Septic Shock enrolment sits around 150 participants.
Median target enrolment is 150 among the 25 trials that report a genuine target (sentinel values excluded). 11 of those (44%) plan for fewer than 100 participants.
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Septic Shock research is mostly interventional.
19 interventional and 6 observational studies make up this index (76% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
25 total, page 1 of 1
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Children's Hospital of Philadelphia
NCT05975671
Assessment for Implementation Methods in Sepsis
Rhode Island Hospital
NCT05491941
Stress Hydrocortisone In Pediatric Septic Shock
Jerry Zimmerman
NCT03401398
Early Versus Late Adjunctive Vasopressin in Septic Shock
The Cleveland Clinic
NCT06709573
Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock
Kingman Regional Medical Center
NCT06122987
A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)
Vivacelle Bio
NCT06072430
Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis
University of Oklahoma
NCT03992378
Early Angiotensin II in the Emergency Department
Brett A Faine
NCT06693726
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
University of Pennsylvania
NCT04855786
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
Henry Ford Health System
NCT05296590
Vasopressin for Septic Shock Pragmatic Trial
Intermountain Health Care
NCT06217562
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Spectral Diagnostics (US)
NCT03901807
Blood Purification for the Treatment of Pathogen Associated Shock
ExThera Medical Corporation
NCT05011656
Predictive algoRithm for EValuation and Intervention in SEpsis
Dascena
NCT03235193
Evaluation of the Heparin Binding Protein Levels in Sepsis
Christiana Care Health Services
NCT02533011
Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock
Methodist Health System
NCT04153578
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock
Spectral Diagnostics (US)
NCT01046669
Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock
University of British Columbia
NCT01867905
Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation
National Institute of General Medical Sciences (NIGMS)
NCT00372502
Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population
Abionic
NCT04409561
HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients
University of Tennessee Medical Center
NCT03710187
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
National Center for Research Resources (NCRR)
NCT00005890
Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock
University of New Mexi
NCT05824767
Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
George Washington University
NCT01393782
Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock
The Cleveland Clinic
NCT03014063
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 3 | 2 |
| Phase 4 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on Septic Shock records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Septic Shock trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Septic Shock page
25 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 Septic Shock trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Spectral Diagnostics (US) sponsors the most Septic Shock trials on record, review their full trial history before evaluating a specific study. See Spectral Diagnostics (US)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Septic Shock condition card totals 25 registered trials; most-linked intervention Angiotensin II; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.