Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05491941 · ClinicalTrials.gov registry record · NA
Assessment for Implementation Methods in Sepsis
A NA study of Septic Shock and Sepsis, Severe, sponsored by Rhode Island Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 10,000
- Enrollment target
- 1
- Study location
NCT05491941: Recruiting NA study of Septic Shock and Sepsis, Severe, sponsored by Rhode Island Hospital.
NCT05491941 is a NA study of Septic Shock and Sepsis, Severe that is actively recruiting participants, run by Rhode Island Hospital. The registered enrollment target is 10,000 participants, above the 4,642-participant average among 24 other Septic Shock trials with a reported enrollment target (115% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05491941, a NA study of Septic Shock and Sepsis, Severe, is actively recruiting participants, sponsored by Rhode Island Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 10,000 participants
- Enrollment target
- 1
- Study location
Study Summary
Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis "bundles" (3-hour bundle) and improved survival. The current proposal is a Hybrid 2, pragmatic, cluster randomized clinical effectiveness/implementation trial evaluating mortality and respiratory failure-based outcomes, in patients admitted to the emergency department with sepsis, comparing the effectiveness of implementation of the hour-1 bundle to 3-hour bundle, while facilitating adherence to both bundles. In addition, 4 distinct sepsis phenotypes will be derived from routine clinical data to identify specific patient phenotypes that allow for a more precision-based application of sepsis bundles in future studies.
Primary Outcome
Mortality associated with death from sepsis.
Conditions Studied
Interventions
- OTHER Sepsis Bundle
Study Locations (1)
Rhode Island
- Rhode Island Hospital - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10,000 participants |
| Start Date | 2022-07-15 |
| Est. Completion | 2027-07-15 |
| Phase | NA |
What NCT05491941 shows while recruiting
NCT05491941 is an interventional study that assigns participants to a tested intervention. Its 10,000 participants enrollment target places it among the larger protocols in the corpus, above the 4,642-participant average among 24 other Septic Shock trials with a reported enrollment target (115% higher).
The record links to 2 conditions, with Septic Shock appearing as the primary indexed condition, and to 1 intervention - of which Sepsis Bundle is the first listed.
NCT05491941 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT05491941 about?
NCT05491941 is a clinical study titled "Assessment for Implementation Methods in Sepsis". Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis "bundles" (3-hour bundle) and improved survival. The current proposal is a Hybrid 2, pragmatic, cluster randomized clinical eff...
What is the current status of trial NCT05491941?
This trial is currently recruiting. It is a NA study. The enrollment target is 10,000 participants. The study started on 2022-07-15. Estimated completion is 2027-07-15.
What conditions does trial NCT05491941 study?
This clinical trial studies the following conditions: Septic Shock, Sepsis, Severe.
What interventions are being tested in trial NCT05491941?
The interventions under investigation include: Sepsis Bundle (OTHER).
Who is sponsoring clinical trial NCT05491941?
This trial is sponsored by Rhode Island Hospital, which has 130 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05491941 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Septic Shock
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05491941's enrollment target sits among peer trials
10,000 3rd of 24 higher than 22 of 24 other Septic Shock trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Septic Shock trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
RECRUITING · NA
-
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
RECRUITING · NA
-
Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis
RECRUITING · NA
-
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
ACTIVE NOT RECRUITING · NA
-
Blood Purification for the Treatment of Pathogen Associated Shock
ACTIVE NOT RECRUITING · NA
-
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00160771 · 10,000 participants
Biomechanics/Motion Analysis Laboratory Data Bank
- NCT00896935 · 10,000 participants
Arizona Cancer Center Biospecimen Repository
- NCT00898235 · 10,000 participants
Collection of Samples and Clinical Data From Patients With Amyloid Diseases
- NCT00992303 · 10,000 participants
Collecting Tissue Samples From Patients With Cancer Undergoing Radiation Therapy and Healthy Participants
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI