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ClinicalTrials.gov 76 recruiting now official registry

Schizophrenia clinical trials

76 of 318 indexed Schizophrenia trials are currently recruiting.

318 US clinical trials · 76 currently recruiting

Schizophrenia is the subject of 318 registered US clinical trials on ClinicalTrials.gov, 76 of them currently open to new participants. 90 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 14 of these trials.

The research picture

Schizophrenia has 318 registered US clinical trials, 76 of them open to new participants right now, about 24% of the total.

76
recruiting participants now
24%
of trials open to enrollment
90
in Phase 3–4 (later-stage)
14
top sponsor: University of Maryland, Baltimore
Phase 147Phase 240Phase 350Phase 440

Active & Recent Trials

318 total, page 3 of 7

COMPLETED Phase 3 841 participants

A Study of Paliperidone Palmitate 6-Month Formulation

Janssen Research & Development

NCT03345342

COMPLETED 800 participants

Neural Oscillations as Genetic and Functional Biomarkers in Normal and Disease States

University of Maryland, Baltimore

NCT01425671

COMPLETED Phase 3 767 participants

Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy

FORUM Pharmaceuticals

NCT01716975

COMPLETED Phase 3 765 participants

A Study of Cariprazine in the Prevention of Relapse of Symptoms in Participants With Schizophrenia

Forest Laboratories

NCT01412060

COMPLETED Phase 3 753 participants

Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy

FORUM Pharmaceuticals

NCT01714661

COMPLETED Phase 2 732 participants

Safety and Efficacy of Cariprazine (RGH-188) in the Acute Exacerbation of Schizophrenia

Forest Laboratories

NCT00694707

COMPLETED Phase 3 702 participants

Pediatric Open-Label Extension Study

Sumitomo Pharma America

NCT01914393

COMPLETED Phase 3 675 participants

A Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label, Long-Term Safety Phase to Evaluate the Efficacy and Safety of TV-44749 in Adults With Schizophrenia

Teva Branded Pharmaceutical Products R&D

NCT05693935

COMPLETED 648 participants

Inpatient Evaluation of Adults With Schizophrenia

National Institute of Mental Health (NIMH)

NCT00001247

COMPLETED Phase 3 635 participants

Relapse Prevention Study in Patients With Schizophrenia

Vanda Pharmaceuticals

NCT01291511

COMPLETED Phase 3 629 participants

A Study of RO4917838 in Participants With Persistent, Predominant Negative Symptoms of Schizophrenia (NN25310)

Hoffmann-La Roche

NCT01192867

COMPLETED Phase 3 624 participants

A Study of RO4917838 (Bitopertin) in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (WN25309)

Hoffmann-La Roche

NCT01192906

COMPLETED Phase 3 611 participants

Clinical Trial of Iclepertin Effect on Cognition and Functional Capacity in Schizophrenia (CONNEX-2)

Boehringer Ingelheim

NCT04846881

COMPLETED Phase 2 603 participants

Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cognition in Outpatients With Schizophrenia

Targacept

NCT01488929

COMPLETED Phase 4 600 participants

Olanzapine Versus Aripiprazole in the Treatment of Acutely Ill Patients With Schizophrenia

Eli Lilly and Company

NCT00103571

COMPLETED Phase 4 600 participants

Efficacy of High Dose Olanzapine for the Treatment of Schizophrenia and Schizoaffective Disorder

Eli Lilly and Company

NCT00100776

COMPLETED 598 participants

Prospective Studies of the Pathogenesis of Schizophrenia

University of North Carolina, Chapel Hill

NCT00877552

COMPLETED Phase 3 593 participants

Efficacy and Safety of Iloperidone Compared With Placebo and Active Control in Subjects With Acute Schizophrenia

Vanda Pharmaceuticals

NCT00254202

COMPLETED Phase 3 566 participants

An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-5)

Karuna Therapeutics

NCT04820309

COMPLETED Phase 3 561 participants

A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study)

Alkermes

NCT02694328

COMPLETED 557 participants

The Management of Schizophrenia in Clinical Practice (MOSAIC)

Genentech

NCT01746134

COMPLETED 502 participants

PET Scanning in Parkinson s Disease

National Institute of Mental Health (NIMH)

NCT00024622

COMPLETED Phase 3 488 participants

Lurasidone HCL - A 6-week Phase 3 Study of Patients With Acute Schizophrenia.

Sumitomo Pharma America

NCT00790192

COMPLETED NA 461 participants

Improving Care and Reducing Cost Study

Northwell Health

NCT02364544

COMPLETED Phase 4 448 participants

Cognitive Skills Training Using Computer for Patients With Severe Mental Illness

Nathan Kline Institute for Psychiatric Research

NCT01036282

COMPLETED NA 400 participants

A Multi-Site Study of Strategies for Implementing Schizophrenia Guidelines

US Department of Veterans Affairs

NCT00013000

COMPLETED Phase 2 400 participants

Culturally Based Family Therapy for Improving Treatment Outcome for People With Schizophrenia

University of Miami

NCT00356317

COMPLETED Phase 3 396 participants

Efficacy and Safety of Adjunctive Pimavanserin for the Treatment of Schizophrenia (ENHANCE-1)

ACADIA Pharmaceuticals

NCT02970292

COMPLETED Phase 2 385 participants

A Trial of 10 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia

AbbVie

NCT05227690

COMPLETED NA 382 participants

Comparison of Video Consent Versus Routine Consent for Participation in Research Studies

University of California, San Diego

NCT00430391

COMPLETED Phase 1 328 participants

A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Paliperidone Palmitate in Patients With Schizophrenia

Janssen Research & Development

NCT01559272

COMPLETED Phase 3 327 participants

Pediatric Schizophrenia Efficacy and Safety Study

Sumitomo Pharma America

NCT01911429

COMPLETED Phase 2 323 participants

A Study of RO4917838 in Combination With Antipsychotic Treatment in Patients With Schizophrenia.

Hoffmann-La Roche

NCT00616798

COMPLETED Phase 2 317 participants

Safety and Cognitive Function Study of EVP-6124 in Patients With Schizophrenia

FORUM Pharmaceuticals

NCT00968851

COMPLETED Phase 3 310 participants

Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder

AbbVie

NCT04578756

COMPLETED 300 participants

Improving Health Services for Veterans With Schizophrenia

US Department of Veterans Affairs

NCT00012961

COMPLETED 296 participants

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

Janssen Scientific Affairs

NCT02600741

COMPLETED NA 292 participants

Early Detection and Intervention for the Prevention of Psychosis

MaineHealth

NCT00531518

COMPLETED Phase 3 291 participants

An Extension of a Long-term Safety Study of ALKS 9072 (Also Known as ALKS 9070)

Alkermes

NCT01895452

COMPLETED Phase 2 287 participants

Study to Evaluate the Efficacy and Safety of Armodafinil as Adjunctive Therapy in Adults With Schizophrenia

Cephalon

NCT00772005

COMPLETED 283 participants

Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

National Institute of Mental Health (NIMH)

NCT00942981

COMPLETED Phase 1 281 participants

Relative Bioavailability of LY03010 Compared to Listed Drug

Luye Pharma Group

NCT04922593

COMPLETED Phase 3 281 participants

A Long-Term Safety and Tolerability Study of ALKS 3831 in Adults With Schizophrenia

Alkermes

NCT02669758

COMPLETED Phase 3 266 participants

A Phase 3, Long-term Safety and Tolerability Study of ALKS 3831 in Adults With Schizophrenia

Alkermes

NCT02873208

COMPLETED Phase 4 256 participants

A Study Comparing the Efficacy and Safety of Ziprasidone and Aripiprazole for the Treatment fo Schizophrenia or Schizoaffective Disorder in Hospitalized Patients

Pfizer's Upjohn has merged with Mylan to form Viatris

NCT00634348

COMPLETED Phase 3 249 participants

Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Adolescent Patients With Schizophrenia

AstraZeneca

NCT00090324

COMPLETED Phase 2 244 participants

Multicenter, Open-label, Safety and Tolerability Study

Otsuka Pharmaceutical Development & Commercialization

NCT01649557

COMPLETED Phase 3 244 participants

A Study Evaluating Lurasidone for The Treatment of Schizophrenia or Schizoaffective Disorder in Subjects Switched From Other Antipsychotic Agents

Sumitomo Pharma America

NCT01143077

COMPLETED NA 240 participants

The Appeal and Impact of E-cigarettes in Smokers With SMI

Dartmouth-Hitchcock Medical Center

NCT03050853

COMPLETED NA 238 participants

The Effectiveness of FMPO in Improving the Quality of Care for Persons With Severe Mental Illness.

US Department of Veterans Affairs

NCT00466323

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 40
Phase 3 50
Phase 4 40

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Schizophrenia Trial Landscape

318 indexed Schizophrenia studies · 76 recruiting (24%).

Phase mix: 90 late (III/IV) vs 87 early (I/II).

Top sponsor: University of Maryland, Baltimore (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Schizophrenia?

PlainTrial tracks 318 US clinical trials for Schizophrenia, of which 76 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Schizophrenia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.