Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04127006 · ClinicalTrials.gov registry record
Rate of Progression in EYS Related Retinal Degeneration
A clinical trial of Retinitis Pigmentosa and Eye Diseases, sponsored by Jaeb Center for Health Research.
- Active
- Registry status
- 103
- Enrollment target
- 19
- Study locations
NCT04127006: Active study of Retinitis Pigmentosa and Eye Diseases, sponsored by Jaeb Center for Health Research.
NCT04127006 is a study of Retinitis Pigmentosa and Eye Diseases that is active but no longer recruiting, run by Jaeb Center for Health Research. The registered enrollment target is 103 participants, below the 259-participant average among 37 other Retinitis Pigmentosa trials with a reported enrollment target (60% lower). The trial reports 19 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04127006, a study of Retinitis Pigmentosa and Eye Diseases, is active but no longer recruiting, sponsored by Jaeb Center for Health Research.
- ACTIVE NOT RECRUITING
- Registry status
- 103 participants
- Enrollment target
- 19
- Study locations
Study Summary
The overall goal of this project funded by the Foundation Fighting Blindness is to characterize the natural history of disease progression in patients with EYS mutations in order to accelerate the development of outcome measures for clinical trials.
Primary Outcome
Measured by static perimetry with topographic analysis (Hill of Vision) and assessed by a central reading center for cohorts 1 and 2.
Conditions Studied
Study Locations (19)
Other
- Hospital for Sick Children - Toronto
- Helsinki University Hospital - Helsinki
- Centre hospitalier National d'Ophtalmologie des Quinze-Vingts - Paris
- University of Tubingen - Tübingen
- Hadassah Medical Center - Jerusalem
- Radboud University - Nijmegen
Florida
- Vitreo-Retinal Associates - Gainesville
- University of Miami: Neuro-ophthalmology Department - Miami
California
- University of California, San Francisco - San Francisco
Colorado
- Colorado Retina Associates - Denver
Georgia
- Emory Eye Center - Atlanta
Maryland
- Wilmer Eye Institute at Johns Hopkins - Baltimore
Massachusetts
- Massachusetts Eye and Ear - Boston
Michigan
- Kellogg Eye Center, University of Michigan - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 103 participants |
| Start Date | 2020-02-25 |
| Est. Completion | 2026-04-01 |
What the registry record for NCT04127006 still lists
NCT04127006 is an observational study that tracks outcomes without assigning an intervention. The registered 103 participants enrollment target is mid-sized for trials with a published cap, below the 259-participant average among 37 other Retinitis Pigmentosa trials with a reported enrollment target (60% lower).
The record links to 2 conditions, with Retinitis Pigmentosa appearing as the primary indexed condition, and to 0 interventions.
NCT04127006 lists 19 locations in 13 states (Other, Florida, California).
Frequently Asked Questions
What is clinical trial NCT04127006 about?
NCT04127006 is a clinical study titled "Rate of Progression in EYS Related Retinal Degeneration". The overall goal of this project funded by the Foundation Fighting Blindness is to characterize the natural history of disease progression in patients with EYS mutations in order to accelerate the development of outcome measures for clinical trials.
What is the current status of trial NCT04127006?
This trial is currently active not recruiting. The enrollment target is 103 participants. The study started on 2020-02-25. Estimated completion is 2026-04-01.
What conditions does trial NCT04127006 study?
This clinical trial studies the following conditions: Retinitis Pigmentosa, Eye Diseases.
Who is sponsoring clinical trial NCT04127006?
This trial is sponsored by Jaeb Center for Health Research, which has 119 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04127006 being conducted?
This trial has 19 study locations across California, Colorado, Florida, Georgia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Retinitis Pigmentosa
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04127006's enrollment target sits among peer trials
103 11th of 37 higher than 27 of 37 other Retinitis Pigmentosa trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Retinitis Pigmentosa trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Promising ROd-cone DYstrophy Gene therapY
RECRUITING · Phase 1
-
High Resolution Retinal Imaging
RECRUITING
-
Safety of a Single, Intravitreal Injection of 6.0M jCell (Famzeretcel) in Retinitis Pigmentosa (RP)
RECRUITING · Phase 2
-
Observational Study to Assess Endpoint Operational Feasibility & Measurement Properties in Patients with Retinal Degeneration
RECRUITING
-
Retinal Imaging in Patients With Inherited Retinal Degenerations
RECRUITING
-
Cell Collection to Study Eye Diseases
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04690348 · 103 participants · Phase 2
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
- NCT05282277 · 103 participants · Phase 4
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
- NCT05566769 · 103 participants · NA
Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD
- NCT05834478 · 103 participants · Phase 3
Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI