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Retinal Disease clinical trials
14 of 20 indexed Retinal Disease trials are currently recruiting.
20 US clinical trials · 14 currently recruiting
Retinal Disease is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 3 of these trials.
The research picture
Retinal Disease has 20 registered US clinical trials, 14 of them open to new participants right now, about 70% of the total.
- 14
- recruiting participants now
- 70%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 3
- top sponsor: National Eye Institute (NEI)
Active & Recent Trials
20 total, page 1 of 1
Inherited Retinal Degenerative Disease Registry
Foundation Fighting Blindness
NCT02435940
Cell Collection to Study Eye Diseases
National Eye Institute (NEI)
NCT01432847
National Eye Institute Biorepository for Retinal Diseases
National Eye Institute (NEI)
NCT01496625
Stem Cell Ophthalmology Treatment Study II
MD Stem Cells
NCT03011541
Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene
National Eye Institute (NEI)
NCT01145196
Intraoperative OCT Guidance of Intraocular Surgery II
Duke University
NCT03713268
Data Gathering for A10900
Optos
NCT07149740
P200TxE Diseased Eye Image Collection
Optos
NCT06269666
Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene
Laboratoires Thea
NCT06627179
COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease
University of Wisconsin, Madison
NCT06380075
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
Laboratoires Thea
NCT06891443
Optimize Pediatric OCT Imaging
Duke University
NCT06139523
A Repeat-Dose, Open-Label, Two Arm Safety and Efficacy Study of Two Doses of VP-001 Administered Intravitreally in Participants With Confirmed PRPF31 Mutation-Associated Retinal Dystrophy, Including Participants Previously Treated With VP001
PYC Therapeutics
NCT06852963
MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby)
PYC Therapeutics
NCT06455826
Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study
Complement Therapeutics
NCT05797896
A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)
ProQR Therapeutics
NCT03913143
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
ProQR Therapeutics
NCT04123626
Stem Cell Models of Best Disease and Other Retinal Degenerative Diseases.
Mayo Clinic
NCT02162953
Topcon 3D OCT-1000 Optical Coherence Tomography System
Topcon Medical Systems
NCT00792259
Natural History Study of CEP290-Related Retinal Degeneration
Editas Medicine
NCT03396042
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 2 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Retinal Disease Trial Landscape
20 indexed Retinal Disease studies · 14 recruiting (70%).
Phase mix: 1 late (III/IV) vs 5 early (I/II).
Top sponsor: National Eye Institute (NEI) (3 trials), 9 others listed. 20 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Retinal Disease?
PlainTrial tracks 20 US clinical trials for Retinal Disease, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Retinal Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.