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NCT02162953 · ClinicalTrials.gov registry record
Stem Cell Models of Best Disease and Other Retinal Degenerative Diseases.
A clinical trial of Retinal Disease and Best Vitelliform Macular Dystrophy, sponsored by Mayo Clinic.
- Completed
- Registry status
- 48
- Enrollment target
- 1
- Study location
NCT02162953: Completed study of Retinal Disease and Best Vitelliform Macular Dystrophy, sponsored by Mayo Clinic.
NCT02162953 is a study of Retinal Disease and Best Vitelliform Macular Dystrophy that has completed, run by Mayo Clinic. The registered enrollment target is 48 participants, below the 1,239-participant average among 19 other Retinal Disease trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02162953, a study of Retinal Disease and Best Vitelliform Macular Dystrophy, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Autosomal recessive bestrophinopathy (ARB) is one of 5 blinding eye diseases caused by mutations in the gene BEST1. These diseases, collectively termed "bestrophinopathies" include ARB, Best vitelliform macular dystrophy (BVMD), adult-onset vitelliform dystrophy (AVMD), autosomal dominant vitreoretinalchoroidopathy (ADVIRC) and retinitis pigmentosa (RP) . Objective: To collect DNA/RNA and skin samples from individuals with ARB or other diseases due to mutations in the gene BEST1. These models will be used to identify and test therapeutic approaches to treating these diseases. Design: Study involves a one time donation of a skin punch biopsy and whole blood. Once the skin biopsy is obtained, skin fibroblasts will be isolated, which will be reprogrammed into iPSCs. RPE cells will be derived from the iPSCs
Conditions Studied
Study Locations (1)
Minnesota
- Mayo Clinic - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2014-02 |
| Est. Completion | 2022-12-31 |
What the finished NCT02162953 record still lists
NCT02162953 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 1,239-participant average among 19 other Retinal Disease trials with a reported enrollment target (96% lower).
The record links to 5 conditions, with Retinal Disease appearing as the primary indexed condition, and to 0 interventions.
NCT02162953 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT02162953 about?
NCT02162953 is a clinical study titled "Stem Cell Models of Best Disease and Other Retinal Degenerative Diseases.". Background: Autosomal recessive bestrophinopathy (ARB) is one of 5 blinding eye diseases caused by mutations in the gene BEST1. These diseases, collectively termed "bestrophinopathies" include ARB, Best vitelliform macular dystrophy (BVMD), adult-onset vitelliform dystrophy (AVMD), autosomal dominan...
What is the current status of trial NCT02162953?
This trial is currently completed. The enrollment target is 48 participants. The study started on 2014-02. Estimated completion is 2022-12-31.
What conditions does trial NCT02162953 study?
This clinical trial studies the following conditions: Retinal Disease, Best Vitelliform Macular Dystrophy, Bestrophinopathy, Adult Onset Vitelliform Macular Dystrophy, Autosomal Dominant Vitreoretinalchoroidopathy.
Who is sponsoring clinical trial NCT02162953?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02162953 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02162953's enrollment target sits among peer trials
48 12th of 19 higher than 7 of 19 other Retinal Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Retinal Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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