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NCT03702725 · ClinicalTrials.gov registry record · Phase 1
Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myeloma
A Phase 1 study of Multiple Myeloma and Refractory Multiple Myeloma, sponsored by Alliance Foundation Trials.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
- 5
- Study locations
NCT03702725: Completed Phase 1 study of Multiple Myeloma and Refractory Multiple Myeloma, sponsored by Alliance Foundation Trials.
NCT03702725 is a Phase 1 study of Multiple Myeloma and Refractory Multiple Myeloma that has completed, run by Alliance Foundation Trials. The registered enrollment target is 14 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (97% lower). The trial reports 5 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03702725, a Phase 1 study of Multiple Myeloma and Refractory Multiple Myeloma, has completed, sponsored by Alliance Foundation Trials.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
- 5
- Study locations
Study Summary
This is a registration, open-label phase 1 study of the combination of ibrutinib/lenalidomide:/dexamethasone in women and men with relapsed/refractory multiple myeloma.
Primary Outcome
DLTs were grade 4 thrombocytopenia; grade 4 neutropenia lasting \> 5 days or febrile neutropenia; grade 3 thrombocytopenia with bleeding or platelet transfusion; grade 3-4 hyperglycemia or a thrombotic/embolic event; or grade 3-4 non-hematologic toxicity (except grade 3 nausea, diarrhea, and vomiting), that were at least probably related to treatment, treatment delays ≥ 21 days for toxicity, and treatment-related death.
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Lenalidomide
- DRUG Ibrutinib
Study Locations (5)
Illinois
- Loyola University Medical Center - Maywood
Massachusetts
- Dana Farber Cancer Institute - Boston
North Carolina
- Wake Forest Baptist Comprehensive Cancer Center - Winston-Salem
Ohio
- The Ohio State University Wexner Medical Center/James Cancer Hospital - Columbus
Rhode Island
- Rhode Island Hospital - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2019-08-29 |
| Est. Completion | 2024-10-04 |
| Phase | Phase 1 |
What the finished NCT03702725 record still lists
NCT03702725 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (97% lower).
The record links to 3 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 3 interventions - of which Dexamethasone is the first listed.
NCT03702725 lists 5 locations in 5 states (Illinois, Massachusetts, North Carolina).
Frequently Asked Questions
What is clinical trial NCT03702725 about?
NCT03702725 is a clinical study titled "Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myeloma". This is a registration, open-label phase 1 study of the combination of ibrutinib/lenalidomide:/dexamethasone in women and men with relapsed/refractory multiple myeloma.
What is the current status of trial NCT03702725?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2019-08-29. Estimated completion is 2024-10-04.
What conditions does trial NCT03702725 study?
This clinical trial studies the following conditions: Multiple Myeloma, Refractory Multiple Myeloma, Multiple Myeloma in Relapse.
What interventions are being tested in trial NCT03702725?
The interventions under investigation include: Dexamethasone (DRUG), Lenalidomide (DRUG), Ibrutinib (DRUG).
Who is sponsoring clinical trial NCT03702725?
This trial is sponsored by Alliance Foundation Trials, which has 20 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03702725 being conducted?
This trial has 5 study locations across Illinois, Massachusetts, North Carolina, Ohio, Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03702725's enrollment target sits among peer trials
14 411th of 438 higher than 25 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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