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NCT03770260 · ClinicalTrials.gov registry record · Phase 1
Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment
A Phase 1 study of Refractory Multiple Myeloma and Recurrent Multiple Myeloma, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 1
- Development phase
- 8
- Enrollment target
- 9
- Study locations
NCT03770260 is a Phase 1 study of Refractory Multiple Myeloma and Recurrent Multiple Myeloma that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 8 participants, below the 48-participant average among 67 other Refractory Multiple Myeloma trials with a reported enrollment target (83% lower). The trial reports 9 study locations across 6 states.
The verdict
NCT03770260, a Phase 1 study of Refractory Multiple Myeloma and Recurrent Multiple Myeloma, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 8 participants
- Enrollment target
- 9
- Study locations
Study Summary
This phase Ib trial studies side effects and best dose of pevonedistat when given together with ixazomib in treating patients with multiple myeloma that has come back or does not respond to treatment. Pevonedistat and ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Conditions Studied
Interventions
- DRUG Ixazomib Citrate
- DRUG Pevonedistat
Study Locations (9)
Florida
- Moffitt Cancer Center-International Plaza - Tampa
- Moffitt Cancer Center - McKinley Campus - Tampa
- Moffitt Cancer Center - Tampa
Connecticut
- Smilow Cancer Center/Yale-New Haven Hospital - New Haven
- Yale University - New Haven
Georgia
- Emory University Hospital/Winship Cancer Institute - Atlanta
Kentucky
- University of Kentucky/Markey Cancer Center - Lexington
North Carolina
- Duke University Medical Center - Durham
Ohio
- Ohio State University Comprehensive Cancer Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2020-02-10 |
| Est. Completion | 2023-07-06 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03770260
The ClinicalTrials.gov registry entry for NCT03770260 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 8 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 48-participant average among 67 other Refractory Multiple Myeloma trials with a reported enrollment target (83% lower). The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Refractory Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions - of which Ixazomib Citrate is the first listed.
NCT03770260 reports 9 study locations spanning 6 distinct geographic areas - top geographies include Florida, Connecticut, Georgia.
Frequently Asked Questions
What is clinical trial NCT03770260 about?
NCT03770260 is a clinical study titled "Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment". This phase Ib trial studies side effects and best dose of pevonedistat when given together with ixazomib in treating patients with multiple myeloma that has come back or does not respond to treatment. Pevonedistat and ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed...
What is the current status of trial NCT03770260?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 8 participants. The study started on 2020-02-10. Estimated completion is 2023-07-06.
What conditions does trial NCT03770260 study?
This clinical trial studies the following conditions: Refractory Multiple Myeloma, Recurrent Multiple Myeloma.
What interventions are being tested in trial NCT03770260?
The interventions under investigation include: Ixazomib Citrate (DRUG), Pevonedistat (DRUG).
Who is sponsoring clinical trial NCT03770260?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03770260 being conducted?
This trial has 9 study locations across Connecticut, Florida, Georgia, Kentucky, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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