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ClinicalTrials.gov 4 recruiting now official registry

Recurrent Glioma clinical trials

4 of 13 indexed Recurrent Glioma trials are currently recruiting.

13 US clinical trials · 4 currently recruiting

Recurrent Glioma is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 5 of these trials.

The research picture

Recurrent Glioma has 13 registered US clinical trials, 4 of them open to new participants right now, about 31% of the total.

4
recruiting participants now
31%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: National Cancer Institute (NCI)
Phase 15Phase 25Phase 31

Active & Recent Trials

13 total, page 1 of 1

RECRUITING NA 120 participants

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

Mayo Clinic

NCT07074756

RECRUITING Phase 2 30 participants

Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment

National Cancer Institute (NCI)

NCT05859334

RECRUITING NA 28 participants

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

Baptist Health South Florida

NCT06397560

RECRUITING Phase 1 21 participants

CARv3-TEAM-E T Cells in Glioblastoma

Marcela V. Maus, M.D.,Ph.D.

NCT05660369

ACTIVE NOT RECRUITING Phase 3 331 participants

Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

Institut de Recherches Internationales Servier

NCT04164901

ACTIVE NOT RECRUITING Phase 2 89 participants

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

National Cancer Institute (NCI)

NCT03212274

ACTIVE NOT RECRUITING Early Phase 1 36 participants

Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma

Jonsson Comprehensive Cancer Center

NCT05045027

ACTIVE NOT RECRUITING Phase 1 29 participants

Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

City of Hope Medical Center

NCT03389230

ACTIVE NOT RECRUITING Phase 2 20 participants

Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03698994

ACTIVE NOT RECRUITING Early Phase 1 16 participants

Niraparib In Recurrent IDH 1/2 Gliomas

Massachusetts General Hospital

NCT05406700

ACTIVE NOT RECRUITING Phase 2 9 participants

Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03213704

COMPLETED Phase 1 86 participants

A Study of PRT811 in Participants With Advanced Solid Tumors, CNS Lymphoma and Gliomas

Prelude Therapeutics

NCT04089449

COMPLETED Phase 2 23 participants

Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)

National Cancer Institute (NCI)

NCT03526250

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Glioma Trial Landscape

13 indexed Recurrent Glioma studies · 4 recruiting (31%).

Phase mix: 1 late (III/IV) vs 10 early (I/II).

Top sponsor: National Cancer Institute (NCI) (5 trials), 8 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Glioma?

PlainTrial tracks 13 US clinical trials for Recurrent Glioma, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Glioma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.