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Acute Decompensated Heart Failure clinical trials
4 of 13 indexed Acute Decompensated Heart Failure trials are currently recruiting.
13 US clinical trials · 4 currently recruiting
Acute Decompensated Heart Failure is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Reprieve Cardiovascular, running 2 of these trials.
The research picture
Acute Decompensated Heart Failure has 13 registered US clinical trials, 4 of them open to new participants right now, about 31% of the total.
- 4
- recruiting participants now
- 31%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Reprieve Cardiovascular
Active & Recent Trials
13 total, page 1 of 1
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
UConn Health
NCT00762008
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
Reprieve Cardiovascular
NCT06898515
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
University of Oklahoma
NCT02898181
Change in Stroke Volume Index After Diuresis for Patients With Decompensated Heart Failure
NYU Langone Health
NCT05240651
DORAYA-HF Early Feasibility Study
Revamp Medical
NCT05206422
IC14 for Treatment of Acute Decompensated Heart Failure
Implicit Bioscience
NCT06556810
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
Abiomed
NCT05291884
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure
Cardiorentis
NCT01661634
Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study
Alere San Diego
NCT01291836
A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure
Trevena
NCT01966601
Evaluation of Cardiopulmonary Diseases by Ultrasound
Echosense
NCT02248831
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)
Reprieve Cardiovascular
NCT05174312
RAAS Optimization for Acute CHF Patients
University of Florida
NCT03695120
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Acute Decompensated Heart Failure Trial Landscape
13 indexed Acute Decompensated Heart Failure studies · 4 recruiting (31%).
Phase mix: 2 late (III/IV) vs 2 early (I/II).
Top sponsor: Reprieve Cardiovascular (2 trials), 9 others listed. 13 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Acute Decompensated Heart Failure?
PlainTrial tracks 13 US clinical trials for Acute Decompensated Heart Failure, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Acute Decompensated Heart Failure?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.