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Acute Decompensated Heart Failure: full-pipeline trial registry
4 of 13 indexed Acute Decompensated Heart Failure trials are currently recruiting.
Corpus placement: #1,315 of 28,707 conditions by registered trial count.
13 US clinical trials · 4 currently recruiting · #1,315 of 28,707 conditions by registered trial count
Acute Decompensated Heart Failure: 13 US clinical trials tracked, 4 recruiting.
Acute Decompensated Heart Failure is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Reprieve Cardiovascular, running 2 of these trials.
Enrollment posture brief
Registry condition acute-decompensated-heart-failure
OPEN 4 | RECR 31% | LATE 2 | EARLY 2 | RANK #1315 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Adolescent Obesity (31% recruiting · 13 trials)
Acute Decompensated Heart Failure lists 4 open slots (31% of 13 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Acute Decompensated Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Acute Decompensated Heart Failure is recruiting below its size-band peers.
4 of 13 indexed trials (30.8%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Acute Decompensated Heart Failure research.
Reprieve Cardiovascular accounts for 2 of 13 trials (15.4%). 12 distinct sponsors appear on at least one study for this condition label.
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Typical Acute Decompensated Heart Failure enrolment sits around 100 participants.
Median target enrolment is 100 among the 13 trials that report a genuine target (sentinel values excluded). 5 of those (38.5%) plan for fewer than 100 participants.
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Acute Decompensated Heart Failure research is mostly interventional.
10 interventional and 3 observational studies make up this index (76.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
13 total, page 1 of 1
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
UConn Health
NCT00762008
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
Reprieve Cardiovascular
NCT06898515
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
University of Oklahoma
NCT02898181
Change in Stroke Volume Index After Diuresis for Patients With Decompensated Heart Failure
NYU Langone Health
NCT05240651
DORAYA-HF Early Feasibility Study
Revamp Medical
NCT05206422
IC14 for Treatment of Acute Decompensated Heart Failure
Implicit Bioscience
NCT06556810
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
Abiomed
NCT05291884
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure
Cardiorentis
NCT01661634
Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study
Alere San Diego
NCT01291836
A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure
Trevena
NCT01966601
Evaluation of Cardiopulmonary Diseases by Ultrasound
Echosense
NCT02248831
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)
Reprieve Cardiovascular
NCT05174312
RAAS Optimization for Acute CHF Patients
University of Florida
NCT03695120
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Acute Decompensated Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Acute Decompensated Heart Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Acute Decompensated Heart Failure page
13 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Acute Decompensated Heart Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Reprieve Cardiovascular sponsors the most Acute Decompensated Heart Failure trials on record, review their full trial history before evaluating a specific study. See Reprieve Cardiovascular's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Acute Decompensated Heart Failure condition card totals 13 registered trials; most-linked intervention Placebo; top US site state Michigan. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.