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ClinicalTrials.gov 9 recruiting now official registry

Pure Autonomic Failure clinical trials

9 of 12 indexed Pure Autonomic Failure trials are currently recruiting.

12 US clinical trials · 9 currently recruiting

Pure Autonomic Failure is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 7 of these trials.

The research picture

Pure Autonomic Failure has 12 registered US clinical trials, 9 of them open to new participants right now, about 75% of the total.

9
recruiting participants now
75%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
7
top sponsor: Vanderbilt University Medical Center
Phase 15

Active & Recent Trials

12 total, page 1 of 1

RECRUITING 800 participants

Natural History Study of Synucleinopathies

NYU Langone Health

NCT01799915

RECRUITING NA 59 participants

CPAP for the Treatment of Supine Hypertension

Vanderbilt University Medical Center

NCT05489575

RECRUITING Phase 1 40 participants

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Daniel Claassen

NCT04246437

RECRUITING Phase 1 34 participants

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Vanderbilt University Medical Center

NCT02897063

RECRUITING Early Phase 1 31 participants

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Vanderbilt University Medical Center

NCT04620382

RECRUITING Phase 1 31 participants

Automated Abdominal Binder for Orthostatic Hypotension

Vanderbilt University Medical Center

NCT03482297

RECRUITING NA 29 participants

Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

Vanderbilt University Medical Center

NCT04782830

RECRUITING Phase 1 29 participants

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Vanderbilt University Medical Center

NCT02429557

RECRUITING NA 20 participants

Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

Vanderbilt University Medical Center

NCT03042988

COMPLETED 428 participants

Synuclein-One Study

CND Life Sciences

NCT04700722

COMPLETED NA 112 participants

Nitric Oxide and the Autonomic Nervous System

Vanderbilt University

NCT00178919

COMPLETED 89 participants

Biomarkers of Risk of Parkinson Disease

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00775853

Phase Distribution

PhaseTrial count
Phase 1 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pure Autonomic Failure Trial Landscape

12 indexed Pure Autonomic Failure studies · 9 recruiting (75%).

Phase mix: 0 late (III/IV) vs 5 early (I/II).

Top sponsor: Vanderbilt University Medical Center (7 trials), 5 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pure Autonomic Failure?

PlainTrial tracks 12 US clinical trials for Pure Autonomic Failure, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pure Autonomic Failure?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.