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ClinicalTrials.gov 5 recruiting now early-phase tilt small index

Adenocarcinoma of the Rectum: early-phase trial registry

5 of 12 indexed Adenocarcinoma of the Rectum trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,429 of 28,707 conditions by registered trial count.

12 US clinical trials · 5 currently recruiting · #1,429 of 28,707 conditions by registered trial count

Adenocarcinoma of the Rectum: 12 US clinical trials tracked, 5 recruiting.

Adenocarcinoma of the Rectum is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 5 of these trials.

Enrollment posture brief

Registry condition adenocarcinoma-of-the-rectum

OPEN 5 | RECR 42% | LATE 0 | EARLY 8 | RANK #1429 | SPON 5

Nearest open-share peer: Alzheimer Disease, Early Onset (42% recruiting · 12 trials)

Adenocarcinoma of the Re (th…42%Acute Myeloid Leukemia in Re41.7%Adiposity41.7%Adherence, Patient16.7%Accelerated Phase Chronic My0%
Open-enrollment share among volume-matched conditions near Adenocarcinoma of the Rectum

Adenocarcinoma of the Rectum lists 5 open slots (42% of 12 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Adenocarcinoma of the Rectum on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Adenocarcinoma of the Rectum is recruiting below its size-band peers.

    5 of 12 indexed trials (41.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Adenocarcinoma of the Rectum research.

    National Cancer Institute (NCI) accounts for 5 of 12 trials (41.7%). 6 distinct sponsors appear on at least one study for this condition label.

  3. Most Adenocarcinoma of the Rectum trials plan to enrol fewer than 100 people.

    Median target enrolment is 43 among the 12 trials that report a genuine target (sentinel values excluded). 10 of those (83.3%) plan for fewer than 100 participants.

  4. Adenocarcinoma of the Rectum research is mostly interventional.

    10 interventional and 2 observational studies make up this index (83.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 23

Open and recent trials

12 total, page 1 of 1

RECRUITING NA 9,500 participants

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

NRG Oncology

NCT05080673

RECRUITING 80 participants

Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation

Memorial Sloan Kettering Cancer Center

NCT04668872

RECRUITING 50 participants

The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors

Case Comprehensive Cancer Center

NCT04624555

RECRUITING Phase 2 37 participants

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Memorial Sloan Kettering Cancer Center

NCT05672524

RECRUITING NA 30 participants

A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer

Memorial Sloan Kettering Cancer Center

NCT06637462

COMPLETED Phase 2 159 participants

Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer

AbbVie (prior sponsor, Abbott)

NCT00707889

COMPLETED Phase 1 48 participants

Vaccine Therapy With or Without Sargramostim in Treating Patients With Advanced or Metastatic Cancer

National Cancer Institute (NCI)

NCT00028496

COMPLETED Phase 1 43 participants

Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

National Cancer Institute (NCI)

NCT00397384

COMPLETED Phase 1 24 participants

Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

National Cancer Institute (NCI)

NCT00006094

COMPLETED Phase 2 20 participants

Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum

Washington University School of Medicine

NCT02641691

COMPLETED Phase 1 20 participants

Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery

National Cancer Institute (NCI)

NCT00433576

COMPLETED Phase 1 15 participants

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Recurrent or Persistent Metastatic Colorectal Cancer

National Cancer Institute (NCI)

NCT00023933

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 3

Named interventions

Most-linked intervention names on Adenocarcinoma of the Rectum records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

fluorouracil Drug
2 trials
oxaliplatin Drug
2 trials
laboratory biomarker analysis Other
2 trials
recombinant fowlpox-CEA(6D)/TRICOM vaccine Biological
1 trials
recombinant fowlpox GM-CSF vaccine adjuvant Biological
1 trials
resveratrol Drug
1 trials
iodine I 131 monoclonal antibody CC49-deltaCH2 Drug
1 trials
ABT-869 Drug
1 trials

US sites by state

Facility locations filed on Adenocarcinoma of the Rectum trials. A trial with sites in several states counts in each.

New York 3 trials
Tennessee 2 trials
Pennsylvania 2 trials
New Jersey 2 trials
Ohio 1 trials
North Carolina 1 trials
Missouri 1 trials
Michigan 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Adenocarcinoma of the Rectum page

12 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Adenocarcinoma of the Rectum condition card totals 12 registered trials; most-linked intervention fluorouracil; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.