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ClinicalTrials.gov 45 recruiting now official registry

Prostate Adenocarcinoma clinical trials

45 of 100 indexed Prostate Adenocarcinoma trials are currently recruiting.

100 US clinical trials · 45 currently recruiting

Prostate Adenocarcinoma is the subject of 100 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is Jonsson Comprehensive Cancer Center, running 9 of these trials.

The research picture

Prostate Adenocarcinoma has 100 registered US clinical trials, 45 of them open to new participants right now, about 45% of the total.

45
recruiting participants now
45%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
9
top sponsor: Jonsson Comprehensive Cancer Center
Phase 114Phase 250Phase 38Phase 41

Active & Recent Trials

100 total, page 2 of 2

ACTIVE NOT RECRUITING NA 208 participants

Germline DNA-Based Radiosensitivity Biomarker Influence on Toxicity Following Prostate Radiotherapy, GARUDA Trial

Jonsson Comprehensive Cancer Center

NCT04624256

ACTIVE NOT RECRUITING NA 201 participants

A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer

Profound Medical

NCT05027477

ACTIVE NOT RECRUITING 179 participants

CT-guided Stereotactic Body Radiation Therapy and MRI-guided Stereotactic Body Radiation Therapy for Prostate Cancer, MIRAGE Study

Jonsson Comprehensive Cancer Center

NCT04384770

ACTIVE NOT RECRUITING NA 146 participants

High-Dose Brachytherapy in Treating Patients With Prostate Cancer

Stanford University

NCT02346253

ACTIVE NOT RECRUITING Phase 2 141 participants

An Investigational Scan (68Ga-PSMA-11 PET) for the Imaging of Prostate Cancer

University of Washington

NCT04777071

ACTIVE NOT RECRUITING Phase 2 140 participants

Fluciclovine F18 or Ga68-PSMA PET/CT to Enhance Prostate Cancer Outcomes

Emory University

NCT03762759

ACTIVE NOT RECRUITING Phase 2 133 participants

White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA

City of Hope Medical Center

NCT04519879

ACTIVE NOT RECRUITING 130 participants

Development and Evaluation of a Quantitative HP MRI for Clinical Prostate Cancer Exam

M.D. Anderson Cancer Center

NCT04286386

ACTIVE NOT RECRUITING Phase 2 115 participants

Clinical Trial of Green Tea Catechins in Men on Active Surveillance

H. Lee Moffitt Cancer Center and Research Institute

NCT04300855

ACTIVE NOT RECRUITING NA 100 participants

CyberKnife Dose Escalation Prostate Cancer Trial

Crozer-Keystone Health System

NCT03822494

ACTIVE NOT RECRUITING Phase 2 93 participants

177-Lutetium-PSMA Before Stereotactic Body Radiotherapy for the Treatment of Oligorecurrent Prostate Cancer, The LUNAR Study

Jonsson Comprehensive Cancer Center

NCT05496959

ACTIVE NOT RECRUITING 92 participants

Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy

Mayo Clinic

NCT01953640

ACTIVE NOT RECRUITING Phase 2 84 participants

A Study to Evaluate Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer

Mayo Clinic

NCT04190446

ACTIVE NOT RECRUITING Phase 2 60 participants

Abiraterone Acetate, Prednisone, and Apalutamide in Treating Patients With Hormone-Naive Metastatic Prostate Cancer

M.D. Anderson Cancer Center

NCT03821792

ACTIVE NOT RECRUITING Phase 2 60 participants

Nivolumab + Docetaxel + ADT in mHSPC Patients With DDRD or Inflamed Tumors

Xiao X. Wei, MD

NCT04126070

ACTIVE NOT RECRUITING 58 participants

Prostate-Specific Membrane Antigen (PSMA) PET Scans in People Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT04030338

ACTIVE NOT RECRUITING Phase 2 45 participants

Apalutamide in Treating Patients With Prostate Cancer Before Radical Prostatectomy

M.D. Anderson Cancer Center

NCT03412396

ACTIVE NOT RECRUITING Phase 2 44 participants

Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer

Andrew McDonald

NCT04743934

ACTIVE NOT RECRUITING Phase 2 40 participants

A Trial of Androgen Deprivation, Docetaxel, and Enzalutamide for Metastatic Prostate Cancer

Wake Forest University Health Sciences

NCT03246347

ACTIVE NOT RECRUITING NA 37 participants

MRI-Mapped Dose-Escalated Salvage Radiotherapy Post-Prostatectomy: The MAPS Trial

University of Miami

NCT01411345

ACTIVE NOT RECRUITING Phase 2 36 participants

A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT05751434

ACTIVE NOT RECRUITING Phase 2 34 participants

Testing the Effects of Low Dose Apalutamide on Prostate-Specific Antigen (PSA) Levels in Men Scheduled for Removal of the Prostate Gland

National Cancer Institute (NCI)

NCT04530552

ACTIVE NOT RECRUITING NA 33 participants

Novel Synthetic T2W MR Imaging and Spin Parameter Mapping Techniques for Screening Prostate Cancer

M.D. Anderson Cancer Center

NCT05055843

ACTIVE NOT RECRUITING Phase 2 25 participants

Radium Ra 223 Dichloride, Hormone Therapy and Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Prostate Cancer

City of Hope Medical Center

NCT03361735

ACTIVE NOT RECRUITING Phase 2 20 participants

Comparison of 18F-rhPSMA-7.3 PET/CT With and Without Furosemide in Biochemical Recurrence of Prostate Cancer

Emory University

NCT05779943

ACTIVE NOT RECRUITING Phase 2 20 participants

Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer

University of Utah

NCT03796767

ACTIVE NOT RECRUITING Phase 1 20 participants

Bicalutamide Implants (Biolen) With Radiation Therapy in Patients With Localized Prostate Cancer

Alessa Therapeutics

NCT04943536

ACTIVE NOT RECRUITING NA 12 participants

Neoadjuvant Dietary Intervention in Intermediate Risk Prostate Cancer

M.D. Anderson Cancer Center

NCT04985565

ACTIVE NOT RECRUITING Phase 2 12 participants

Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery

Roswell Park Cancer Institute

NCT03899987

ACTIVE NOT RECRUITING Early Phase 1 9 participants

Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression

Beth Israel Deaconess Medical Center

NCT05683964

ACTIVE NOT RECRUITING Phase 2 8 participants

Golimumab and Apalutamide for the Treatment of Castration-Resistant Prostate Cancer, TRAMP Study

University of Washington

NCT05960578

ACTIVE NOT RECRUITING Phase 1 6 participants

Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer

Emory University

NCT06105918

COMPLETED Phase 3 1,138 participants

Gallium Ga 68-labeled PSMA-11 PET/CT in Detecting Recurrent Prostate Cancer in Patients After Initial Therapy

Jonsson Comprehensive Cancer Center

NCT02940262

COMPLETED Phase 2 937 participants

68GA-PSMA-11 PET/CT Scan in Impacting Treatment Strategies for Patients With Prostate Cancer

Jonsson Comprehensive Cancer Center

NCT04050215

COMPLETED NA 550 participants

Increasing the Dose of Survivorship Care Planning in Improving Care and Outcomes in Prostate Cancer Survivors Receiving Androgen Deprivation Therapy

NRG Oncology

NCT03860961

COMPLETED NA 400 participants

68Ga-PSMA-11 PET/CT in Imaging Patients With Intermediate or High Risk Prostate Cancer Before Surgery

Jonsson Comprehensive Cancer Center

NCT03368547

COMPLETED Phase 2 300 participants

C11-Sodium Acetate PET/CT Imaging for Metastatic Disease in Intermediate-to-high Risk Prostate Adenocarcinoma

Phoenix Molecular Imaging

NCT01530269

COMPLETED NA 132 participants

Cholecalciferol Supplement in Treating Patients With Localized Prostate Cancer Undergoing Observation

Roswell Park Cancer Institute

NCT00887432

COMPLETED Phase 2 122 participants

68Ga-RM2 PET/MRI in Biochemically Recurrent Prostate Cancer

Andrei Iagaru

NCT02624518

COMPLETED Phase 2 112 participants

Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer

Mayo Clinic

NCT00170157

COMPLETED NA 83 participants

CyberKnife® as Monotherapy or Boost SBRT for Intermediate or High Risk Localized Prostate Cancer

Wake Forest University Health Sciences

NCT01985828

COMPLETED Phase 2 78 participants

Tivantinib in Treating Patients With Metastatic Prostate Cancer

National Cancer Institute (NCI)

NCT01519414

COMPLETED Phase 1 41 participants

Fluorescent Imaging of Nerves With Illuminare-1 During Surgery

Memorial Sloan Kettering Cancer Center

NCT04983862

COMPLETED Phase 2 31 participants

Durvalumab and Tremelimumab in Treating Chemotherapy Naive Patients With Metastatic Castration-Resistant Prostate Cancer

M.D. Anderson Cancer Center

NCT03204812

COMPLETED Phase 1 29 participants

An Investigational Scan (rh PSMA 7.3 PET/MRI) for the Detection of Recurrent Disease and Aid in Radiotherapy Planning in Biochemically Recurrent Prostate Cancer

M.D. Anderson Cancer Center

NCT04978675

COMPLETED Phase 2 25 participants

Soy Bread Diet in Improving Immune Function in Participants With Prostate Cancer

Ohio State University Comprehensive Cancer Center

NCT03654638

COMPLETED Phase 1 22 participants

Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring

NRG Oncology

NCT04037254

COMPLETED Phase 2 15 participants

Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer

National Cancer Institute (NCI)

NCT01325311

COMPLETED Phase 2 13 participants

Combining EPI-7386 With Enzalutamide and Androgen Deprivation Therapy for Metastatic Hormone-Sensitive Prostate Cancer

Pedro Barata, MD, MSc

NCT06312670

COMPLETED 5 participants

CCRO044: Quality of Life Assessments Associated With a Physician Communication Intervention for Prostate Cancer Patients

University of California, Davis

NCT03780023

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Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 50
Phase 3 8
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Prostate Adenocarcinoma Trial Landscape

100 indexed Prostate Adenocarcinoma studies · 45 recruiting (45%).

Phase mix: 9 late (III/IV) vs 64 early (I/II).

Top sponsor: Jonsson Comprehensive Cancer Center (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Prostate Adenocarcinoma?

PlainTrial tracks 100 US clinical trials for Prostate Adenocarcinoma, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Prostate Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.