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ClinicalTrials.gov 9 recruiting now official registry

Germ Cell Tumor clinical trials

9 of 20 indexed Germ Cell Tumor trials are currently recruiting.

20 US clinical trials · 9 currently recruiting

Germ Cell Tumor is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is Seattle Children's Hospital, running 4 of these trials.

The research picture

Germ Cell Tumor has 20 registered US clinical trials, 9 of them open to new participants right now, about 45% of the total.

9
recruiting participants now
45%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
4
top sponsor: Seattle Children's Hospital
Phase 18Phase 24Phase 33

Active & Recent Trials

20 total, page 1 of 1

RECRUITING Phase 3 1,780 participants

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

Children's Oncology Group

NCT03067181

RECRUITING 1,151 participants

Molecular Epidemiology of Pediatric Germ Cell Tumors

Children's Oncology Group

NCT05564026

RECRUITING 1,000 participants

Germ Cell Tumor and Testicular Tumor DNA Registry

Memorial Sloan Kettering Cancer Center

NCT02099734

RECRUITING Phase 3 500 participants

Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours

University of Sydney

NCT02582697

RECRUITING Phase 1 282 participants

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

Xencor

NCT06276491

RECRUITING Phase 1 90 participants

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Seattle Children's Hospital

NCT04185038

RECRUITING Phase 2 64 participants

Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

Nabil Adra

NCT04804007

RECRUITING Phase 1 38 participants

Maintenance Zanzalintinib With Etoposide After HDCT in GCT

Indiana University

NCT06937866

RECRUITING Phase 2 35 participants

A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy

Wake Forest University Health Sciences

NCT06866964

ACTIVE NOT RECRUITING 956 participants

A Study of miRNA 371 in Patients With Germ Cell Tumors

SWOG Cancer Research Network

NCT04435756

ACTIVE NOT RECRUITING Phase 3 420 participants

Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors

Alliance for Clinical Trials in Oncology

NCT02375204

ACTIVE NOT RECRUITING Phase 1 68 participants

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

NCT04483778

ACTIVE NOT RECRUITING Phase 2 50 participants

A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

Jennifer King

NCT04876456

ACTIVE NOT RECRUITING NA 45 participants

Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors

Massachusetts General Hospital

NCT01049230

ACTIVE NOT RECRUITING Phase 1 44 participants

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

NCT03618381

ACTIVE NOT RECRUITING Phase 2 30 participants

Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors

Memorial Sloan Kettering Cancer Center

NCT03158064

ACTIVE NOT RECRUITING Phase 1 10 participants

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Seattle Children's Hospital

NCT03500991

COMPLETED Phase 1 18 participants

Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors

Emory University

NCT01331135

COMPLETED Phase 1 14 participants

Study of the Hypomethylating Drug Guadecitabine (SGI-110) Plus Cisplatin in Relapsed Refractory Germ Cell Tumors

Nasser Hanna

NCT02429466

COMPLETED 10 participants

Role of Axumin PET Scan in Germ Cell Tumor

University of Texas Southwestern Medical Center

NCT03426865

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 4
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Germ Cell Tumor Trial Landscape

20 indexed Germ Cell Tumor studies · 9 recruiting (45%).

Phase mix: 3 late (III/IV) vs 12 early (I/II).

Top sponsor: Seattle Children's Hospital (4 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Germ Cell Tumor?

PlainTrial tracks 20 US clinical trials for Germ Cell Tumor, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Germ Cell Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.