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NCT04286386 · ClinicalTrials.gov registry record
Development and Evaluation of a Quantitative HP MRI for Clinical Prostate Cancer Exam
A clinical trial of Prostate Adenocarcinoma, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- 130
- Enrollment target
- 1
- Study location
NCT04286386: Active study of Prostate Adenocarcinoma, sponsored by M.D. Anderson Cancer Center.
NCT04286386 is a study of Prostate Adenocarcinoma that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 130 participants, below the 217-participant average among 99 other Prostate Adenocarcinoma trials with a reported enrollment target (40% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04286386, a study of Prostate Adenocarcinoma, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- 130 participants
- Enrollment target
- 1
- Study location
Study Summary
This trial examines if a prostate magnetic resonance spectroscopic imaging can be performed on a 3T scanner using an investigational contrast called hyperpolarized 13-C pyruvate for the development of a clinical prostate cancer exam. 3T refers to the strength of the magnetic resonance spectroscopic imaging (MRSI) machine. MRSI is a magnetic resonance imaging (MRI) technique that can show certain chemical differences in healthy and diseased prostate tumor tissue compared to standard multiparametric MRI that may not detect the tumor. Hyperpolarized (HP) 13-C pyruvate is a contrast drug that may help the scanner see the tumor site better during imaging. Hyperpolarization of 13-C pyruvate may allow pyruvate and its metabolites to be detected upon injection, which in turn, allow the prostate cancer to be found and treated.
Primary Outcome
Will be assessed using a test-retest study design. Will be summarized by the intra-class correlation coefficient (ICC). Data from patients at both MD Anderson and University of San Fransisco, San Fransisco (UCSF) will be pooled if possible to increase significance. Bland-Altman analysis will be included if the ICC proves unreliable as a measure of reproducibility. ICC is sensitive to data range; thus, Bland-Altman plot, limits of agreement, repeatability coefficient, and the within-patient coeff
Conditions Studied
Interventions
- PROCEDURE Surgical Procedure
- PROCEDURE Magnetic Resonance Spectroscopic Imaging
- OTHER Hyperpolarized Carbon C 13 Pyruvate
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2019-12-19 |
| Est. Completion | 2026-04-30 |
What the registry record for NCT04286386 still lists
NCT04286386 is an observational study that tracks outcomes without assigning an intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, below the 217-participant average among 99 other Prostate Adenocarcinoma trials with a reported enrollment target (40% lower).
The record links to 1 condition, with Prostate Adenocarcinoma appearing as the primary indexed condition, and to 3 interventions - of which Surgical Procedure is the first listed.
NCT04286386 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04286386 about?
NCT04286386 is a clinical study titled "Development and Evaluation of a Quantitative HP MRI for Clinical Prostate Cancer Exam". This trial examines if a prostate magnetic resonance spectroscopic imaging can be performed on a 3T scanner using an investigational contrast called hyperpolarized 13-C pyruvate for the development of a clinical prostate cancer exam. 3T refers to the strength of the magnetic resonance spectroscopic ...
What is the current status of trial NCT04286386?
This trial is currently active not recruiting. The enrollment target is 130 participants. The study started on 2019-12-19. Estimated completion is 2026-04-30.
What conditions does trial NCT04286386 study?
This clinical trial studies the following conditions: Prostate Adenocarcinoma.
What interventions are being tested in trial NCT04286386?
The interventions under investigation include: Surgical Procedure (PROCEDURE), Magnetic Resonance Spectroscopic Imaging (PROCEDURE), Hyperpolarized Carbon C 13 Pyruvate (OTHER).
Who is sponsoring clinical trial NCT04286386?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04286386 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Prostate Adenocarcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04286386's enrollment target sits among peer trials
130 32nd of 99 higher than 68 of 99 other Prostate Adenocarcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Prostate Adenocarcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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