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2026 data Public-data reference. official source

Postural Tachycardia Syndrome

Open-data reference.

20 US clinical trials · 4 currently recruiting

Active & Recent Trials

RECRUITING 500 participants

Inappropriate Sinus Tachycardia Registry

AtriCure

NCT05107635

RECRUITING NA 80 participants

Autoimmune Basis for Postural Tachycardia Syndrome

University of Oklahoma

NCT05043051

RECRUITING Phase 2 50 participants

A Study of Pyridostigmine in Postural Tachycardia Syndrome

Mayo Clinic

NCT00409435

RECRUITING NA 36 participants

Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?

Virginia Commonwealth University

NCT05618054

ACTIVE NOT RECRUITING 200 participants

POTS NET mRNA Functional Correlation With NET Activity

Vanderbilt University Medical Center

NCT03218761

ACTIVE NOT RECRUITING NA 110 participants

Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening

Vanderbilt University

NCT01783288

ACTIVE NOT RECRUITING 100 participants

Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)

Satish R. Raj

NCT00692471

ACTIVE NOT RECRUITING Early Phase 1 48 participants

Autonomic Determinants of POTS - Pilot 2

Vanderbilt University Medical Center

NCT04140721

ACTIVE NOT RECRUITING Early Phase 1 48 participants

Autonomic Determinants of POTS - Pilot1

Vanderbilt University Medical Center

NCT04050410

ACTIVE NOT RECRUITING NA 40 participants

Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Vanderbilt University Medical Center

NCT01000350

ACTIVE NOT RECRUITING NA 30 participants

Acute Salt Handling in Orthostatic Intolerance

Vanderbilt University

NCT00581633

ACTIVE NOT RECRUITING NA 30 participants

Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)

Alfredo Gamboa

NCT00962728

ACTIVE NOT RECRUITING NA 25 participants

Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.

University of California, San Diego

NCT05409651

ACTIVE NOT RECRUITING NA 21 participants

fMRI in Postural Tachycardia Syndrome

Milton S. Hershey Medical Center

NCT04137757

ACTIVE NOT RECRUITING Early Phase 1 20 participants

Modafinil and Cognitive Function in POTS

Vanderbilt University Medical Center

NCT01988883

ACTIVE NOT RECRUITING Phase 1 11 participants

Vagal Stimulation in POTS

Vanderbilt University Medical Center

NCT03124355

COMPLETED NA 95 participants

Qualitative Sweat Distribution During Tilt Table Procedure

Nationwide Children's Hospital

NCT02329548

COMPLETED 60 participants

Cognitive Dysfunction in Postural Tachycardia Syndrome

Vanderbilt University

NCT01366963

COMPLETED NA 40 participants

Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)

Mayo Clinic

NCT06268288

COMPLETED 26 participants

Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome

Vanderbilt University Medical Center

NCT01308099

Phase Distribution

PhaseTrial count
Early Phase 1 4
Phase 2 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Postural Tachycardia Syndrome Trial Landscape

ClinicalTrials.gov lists 20 US studies indexed under Postural Tachycardia Syndrome, and 4 of those are currently open to recruitment — roughly 20% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Postural Tachycardia Syndrome shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Postural Tachycardia Syndrome is led by Vanderbilt University Medical Center with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 20 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Postural Tachycardia Syndrome?

PlainTrial tracks 20 US clinical trials for Postural Tachycardia Syndrome, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Postural Tachycardia Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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