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NCT05409651 · ClinicalTrials.gov registry record · NA
Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.
A NA study of Postural Tachycardia Syndrome, sponsored by University of California, San Diego.
- Active
- Registry status
- NA
- Development phase
- 25
- Enrollment target
- 1
- Study location
NCT05409651 is a NA study of Postural Tachycardia Syndrome that is active but no longer recruiting, run by University of California, San Diego. The registered enrollment target is 25 participants, below the 81-participant average among 19 other Postural Tachycardia Syndrome trials with a reported enrollment target (69% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05409651, a NA study of Postural Tachycardia Syndrome, is active but no longer recruiting, sponsored by University of California, San Diego.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
- 1
- Study location
Study Summary
The mechanisms underlying POTS are not well understood. Though heterogeneous in nature, patients often present with symptoms that include fatigue, orthostatic lightheadedness and tachycardia, "brain fog", shortness of breath, and sleep disruption. The central mediator that links observations in disease entities similar to POTS is energy use and balance driven by mitochondrial health. Mitochondrial dysfunction (i.e. respiration defects, reactive oxygen species (ROS) generation, and structural abnormalities) are hallmarks of currently defined syndromes that resemble POTS symptomatology. Many patients with POTS have underlying immune system dysfunction, which, when treated, may improve the patient's overall health. Though autoimmunity has been demonstrated in POTS, overall immune dysregulation may be broader and include immune cell exhaustion and persistent inflammatory cytokine responses. Immune dysfunction including cellular exhaustion and persistent inflammation has been linked to mitochondrial function. Therefore, we hypothesize that a unifying feature of POTS results from latent or continued mitochondrial/immune dysfunction which then impacts multi-organ energy imbalance and immune homeostasis. Understanding and targeting mitochondria utilizing established, novel, and directed approaches including time-restricted eating (TRE) will help to unravel common etiologies and help us to better diagnose, manage, and treat POTS.
Conditions Studied
Interventions
- BEHAVIORAL Time restricted eating
Study Locations (1)
California
- Altman Clinical and Translational Research Institute - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2022-07-01 |
| Est. Completion | 2025-06 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05409651
The ClinicalTrials.gov registry entry for NCT05409651 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 25 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 81-participant average among 19 other Postural Tachycardia Syndrome trials with a reported enrollment target (69% lower). The listed sponsor is University of California, San Diego, which has 775 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Postural Tachycardia Syndrome appearing as the primary indexed condition, and to 1 intervention - of which Time restricted eating is the first listed.
NCT05409651 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT05409651 about?
NCT05409651 is a clinical study titled "Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.". The mechanisms underlying POTS are not well understood. Though heterogeneous in nature, patients often present with symptoms that include fatigue, orthostatic lightheadedness and tachycardia, "brain fog", shortness of breath, and sleep disruption. The central mediator that links observations in dise...
What is the current status of trial NCT05409651?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 25 participants. The study started on 2022-07-01. Estimated completion is 2025-06.
What conditions does trial NCT05409651 study?
This clinical trial studies the following conditions: Postural Tachycardia Syndrome.
What interventions are being tested in trial NCT05409651?
The interventions under investigation include: Time restricted eating (BEHAVIORAL).
Who is sponsoring clinical trial NCT05409651?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05409651 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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