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NCT04137757 · ClinicalTrials.gov registry record · NA
fMRI in Postural Tachycardia Syndrome
A NA study of Postural Tachycardia Syndrome, sponsored by Milton S. Hershey Medical Center.
- Active
- Registry status
- NA
- Development phase
- 21
- Enrollment target
- 1
- Study location
NCT04137757: Active NA study of Postural Tachycardia Syndrome, sponsored by Milton S. Hershey Medical Center.
NCT04137757 is a NA study of Postural Tachycardia Syndrome that is active but no longer recruiting, run by Milton S. Hershey Medical Center. The registered enrollment target is 21 participants, below the 82-participant average among 19 other Postural Tachycardia Syndrome trials with a reported enrollment target (74% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04137757, a NA study of Postural Tachycardia Syndrome, is active but no longer recruiting, sponsored by Milton S. Hershey Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
- 1
- Study location
Study Summary
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is accompanied by symptoms such as dizziness and fatigue. One of the most under appreciated and bothersome symptoms of POTS is impaired cognition or "brain fog," which occurs to a level that interferes with daily activities such as work and education. Despite this high impact, the reasons why POTS patients have problems with cognition are not well understood. This project will test the overall hypothesis that "brain fog" in POTS is related to increased activation of cognitive brain regions during mental tasks when compared with healthy subjects, and that this activation is exacerbated by in the presence of orthostatic stress.
Primary Outcome
The change in activation of cognitive brain regions measured by blood oxygen dependent functional magnetic resonance imaging following cognitive tasks and orthostatic stress.
Conditions Studied
Interventions
- OTHER Lower Body Negative Pressure
- OTHER Sham Pressure
Study Locations (1)
Pennsylvania
- Penn State Milton S. Hershey Medical Center - Hershey
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2022-02-18 |
| Est. Completion | 2026-12-01 |
| Phase | NA |
What the registry record for NCT04137757 still lists
NCT04137757 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 82-participant average among 19 other Postural Tachycardia Syndrome trials with a reported enrollment target (74% lower).
The record links to 1 condition, with Postural Tachycardia Syndrome appearing as the primary indexed condition, and to 2 interventions - of which Lower Body Negative Pressure is the first listed.
NCT04137757 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04137757 about?
NCT04137757 is a clinical study titled "fMRI in Postural Tachycardia Syndrome". Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is accompanied by symptoms such as dizziness and fatigue. One of the most...
What is the current status of trial NCT04137757?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 21 participants. The study started on 2022-02-18. Estimated completion is 2026-12-01.
What conditions does trial NCT04137757 study?
This clinical trial studies the following conditions: Postural Tachycardia Syndrome.
What interventions are being tested in trial NCT04137757?
The interventions under investigation include: Lower Body Negative Pressure (OTHER), Sham Pressure (OTHER).
Who is sponsoring clinical trial NCT04137757?
This trial is sponsored by Milton S. Hershey Medical Center, which has 396 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04137757 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Postural Tachycardia Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04137757's enrollment target sits among peer trials
21 18th of 19 higher than 2 of 19 other Postural Tachycardia Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postural Tachycardia Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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