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NCT01988883 · ClinicalTrials.gov registry record · Early Phase 1
Modafinil and Cognitive Function in POTS
A Early Phase 1 study of Postural Tachycardia Syndrome, sponsored by Vanderbilt University Medical Center.
- Active
- Registry status
- Early Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT01988883: Active Early Phase 1 study of Postural Tachycardia Syndrome, sponsored by Vanderbilt University Medical Center.
NCT01988883 is a Early Phase 1 study of Postural Tachycardia Syndrome that is active but no longer recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 20 participants, below the 82-participant average among 19 other Postural Tachycardia Syndrome trials with a reported enrollment target (76% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01988883, a Early Phase 1 study of Postural Tachycardia Syndrome, is active but no longer recruiting, sponsored by Vanderbilt University Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
A common complaint among patients with Postural Tachycardia Syndrome (POTS) is "brain fog" or difficulty concentrating. This problem is poorly understood. The purpose of this study is to better understand the cognitive dysfunction associated POTS, and to determine optimal treatment strategies for this condition. In this study, the investigators will test the hypothesis that acute administration of the psychostimulant drug modafinil can improve seated measures of cognitive function in patients with POTS.
Primary Outcome
This outcome will be assessed using the CogState Identification Task which provides a continuous variable for visual attention performance speed.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Modafinil
- DRUG Propranolol
Study Locations (1)
Tennessee
- Vanderbilt University - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2014-10 |
| Est. Completion | 2026-12 |
| Phase | Early Phase 1 |
What the registry record for NCT01988883 still lists
NCT01988883 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 82-participant average among 19 other Postural Tachycardia Syndrome trials with a reported enrollment target (76% lower).
The record links to 1 condition, with Postural Tachycardia Syndrome appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT01988883 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT01988883 about?
NCT01988883 is a clinical study titled "Modafinil and Cognitive Function in POTS". A common complaint among patients with Postural Tachycardia Syndrome (POTS) is "brain fog" or difficulty concentrating. This problem is poorly understood. The purpose of this study is to better understand the cognitive dysfunction associated POTS, and to determine optimal treatment strategies for t...
What is the current status of trial NCT01988883?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 20 participants. The study started on 2014-10. Estimated completion is 2026-12.
What conditions does trial NCT01988883 study?
This clinical trial studies the following conditions: Postural Tachycardia Syndrome.
What interventions are being tested in trial NCT01988883?
The interventions under investigation include: Placebo (DRUG), Modafinil (DRUG), Propranolol (DRUG).
Who is sponsoring clinical trial NCT01988883?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01988883 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Postural Tachycardia Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01988883's enrollment target sits among peer trials
20 19th of 19 higher than 1 of 19 other Postural Tachycardia Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postural Tachycardia Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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-
A Study of Pyridostigmine in Postural Tachycardia Syndrome
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