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ClinicalTrials.gov 3 recruiting now official registry

Postural Orthostatic Tachycardia Syndrome clinical trials

3 of 12 indexed Postural Orthostatic Tachycardia Syndrome trials are currently recruiting.

12 US clinical trials · 3 currently recruiting

Postural Orthostatic Tachycardia Syndrome is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University, running 2 of these trials.

The research picture

Postural Orthostatic Tachycardia Syndrome has 12 registered US clinical trials, 3 of them open to new participants right now, about 25% of the total.

3
recruiting participants now
25%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Vanderbilt University
Phase 21Phase 31

Active & Recent Trials

12 total, page 1 of 1

RECRUITING NA 100,500 participants

The Long COVID-19 Wearable Device Study

Scripps Translational Science Institute

NCT05741112

RECRUITING 350 participants

Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

University of Texas Southwestern Medical Center

NCT06292104

RECRUITING NA 90 participants

Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome

Medical College of Wisconsin

NCT05212129

ACTIVE NOT RECRUITING NA 260 participants

Pathophysiology of Orthostatic Intolerance

Satish R. Raj

NCT00608725

ACTIVE NOT RECRUITING 212 participants

Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome

Vanderbilt University

NCT02196376

ACTIVE NOT RECRUITING 70 participants

Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome

Vanderbilt University Medical Center

NCT05344599

ACTIVE NOT RECRUITING NA 30 participants

Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)

Alfredo Gamboa

NCT00962728

ACTIVE NOT RECRUITING NA 18 participants

Transdermal Vagal Stimulation for POTS

Vanderbilt University

NCT02281097

COMPLETED Phase 2 45 participants

The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

Brigham and Women's Hospital

NCT03674541

COMPLETED NA 40 participants

Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)

Mayo Clinic

NCT06268288

COMPLETED NA 38 participants

Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome

Vanderbilt University Medical Center

NCT01563107

COMPLETED Phase 3 37 participants

Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome

University of California, San Diego

NCT03182725

Phase Distribution

PhaseTrial count
Phase 2 1
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Postural Orthostatic Tachycardia Syndrome Trial Landscape

12 indexed Postural Orthostatic Tachycardia Syndrome studies · 3 recruiting (25%).

Phase mix: 1 late (III/IV) vs 1 early (I/II).

Top sponsor: Vanderbilt University (2 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Postural Orthostatic Tachycardia Syndrome?

PlainTrial tracks 12 US clinical trials for Postural Orthostatic Tachycardia Syndrome, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Postural Orthostatic Tachycardia Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.