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NCT05344599 · ClinicalTrials.gov registry record
Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome
A clinical trial of Postural Orthostatic Tachycardia Syndrome and Acute Hepatic Porphyria, sponsored by Vanderbilt University Medical Center.
- Active
- Registry status
- 70
- Enrollment target
- 1
- Study location
NCT05344599: Active study of Postural Orthostatic Tachycardia Syndrome and Acute Hepatic Porphyria, sponsored by Vanderbilt University Medical Center.
NCT05344599 is a study of Postural Orthostatic Tachycardia Syndrome and Acute Hepatic Porphyria that is active but no longer recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 70 participants, below the 9,238-participant average among 11 other Postural Orthostatic Tachycardia Syndrome trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05344599, a study of Postural Orthostatic Tachycardia Syndrome and Acute Hepatic Porphyria, is active but no longer recruiting, sponsored by Vanderbilt University Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women. The condition is characterized by a rapid increase in heart rate (HR) that occurs on standing, and chronic symptoms of cerebral hypoperfusion leading to lightheadedness, dizziness, and blurred vision. The acute hepatic porphyrias(AHP)are among the diseases that present with autonomic cardiovascular(tachycardia)and neurovisceral symptoms (abdominal pain) among others; they present with acute exacerbations Given that there is available treatment for AHP that change the natural progression of the disease, study focuses to investigate the occurrence of AHP in POTS and determine the clinical and neuro-hormonal characteristic of the POTS subgroup that will likely benefit from AHP screening. This study has one visit that involves, answering some questionnaires, coming to the lab for blood work, genetic testing, and some autonomic function tests. About 50 people will take part in this study.
Primary Outcome
Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Genetic Testing
- DIAGNOSTIC_TEST Autonomic Function Testing
- DIAGNOSTIC_TEST Urine Testing
- DIAGNOSTIC_TEST Blood laboratory Testing
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2022-01-19 |
| Est. Completion | 2026-06-30 |
What the registry record for NCT05344599 still lists
NCT05344599 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 9,238-participant average among 11 other Postural Orthostatic Tachycardia Syndrome trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Postural Orthostatic Tachycardia Syndrome appearing as the primary indexed condition, and to 4 interventions - of which Genetic Testing is the first listed.
NCT05344599 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT05344599 about?
NCT05344599 is a clinical study titled "Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome". Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women. The condition is characterized by a rapid increase in heart rate (HR) that occurs on standing, and chronic symptoms o...
What is the current status of trial NCT05344599?
This trial is currently active not recruiting. The enrollment target is 70 participants. The study started on 2022-01-19. Estimated completion is 2026-06-30.
What conditions does trial NCT05344599 study?
This clinical trial studies the following conditions: Postural Orthostatic Tachycardia Syndrome, Acute Hepatic Porphyria.
What interventions are being tested in trial NCT05344599?
The interventions under investigation include: Genetic Testing (DIAGNOSTIC_TEST), Autonomic Function Testing (DIAGNOSTIC_TEST), Urine Testing (DIAGNOSTIC_TEST), Blood laboratory Testing (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05344599?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05344599 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05344599's enrollment target sits among peer trials
70 6th of 11 higher than 6 of 11 other Postural Orthostatic Tachycardia Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Postural Orthostatic Tachycardia Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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