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NCT05344599 · ClinicalTrials.gov registry record

Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome

A clinical trial of Postural Orthostatic Tachycardia Syndrome and Acute Hepatic Porphyria, sponsored by Vanderbilt University Medical Center.

Active
Registry status
70
Enrollment target
1
Study location

NCT05344599 is a study of Postural Orthostatic Tachycardia Syndrome and Acute Hepatic Porphyria that is active but no longer recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 70 participants, below the 9,238-participant average among 11 other Postural Orthostatic Tachycardia Syndrome trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05344599, a study of Postural Orthostatic Tachycardia Syndrome and Acute Hepatic Porphyria, is active but no longer recruiting, sponsored by Vanderbilt University Medical Center.

ACTIVE NOT RECRUITING
Registry status
70 participants
Enrollment target
1
Study location

Study Summary

Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women. The condition is characterized by a rapid increase in heart rate (HR) that occurs on standing, and chronic symptoms of cerebral hypoperfusion leading to lightheadedness, dizziness, and blurred vision. The acute hepatic porphyrias(AHP)are among the diseases that present with autonomic cardiovascular(tachycardia)and neurovisceral symptoms (abdominal pain) among others; they present with acute exacerbations Given that there is available treatment for AHP that change the natural progression of the disease, study focuses to investigate the occurrence of AHP in POTS and determine the clinical and neuro-hormonal characteristic of the POTS subgroup that will likely benefit from AHP screening. This study has one visit that involves, answering some questionnaires, coming to the lab for blood work, genetic testing, and some autonomic function tests. About 50 people will take part in this study.

Conditions Studied

Postural Orthostatic Tachycardia Syndrome Acute Hepatic Porphyria

Interventions

  • DIAGNOSTIC_TEST Genetic Testing
  • DIAGNOSTIC_TEST Autonomic Function Testing
  • DIAGNOSTIC_TEST Urine Testing
  • DIAGNOSTIC_TEST Blood laboratory Testing

Study Locations (1)

Tennessee

  • Vanderbilt University Medical Center - Nashville

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2022-01-19
Est. Completion 2026-06-30

Sponsor

Vanderbilt University Medical Center

677 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05344599

The ClinicalTrials.gov registry entry for NCT05344599 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 9,238-participant average among 11 other Postural Orthostatic Tachycardia Syndrome trials with a reported enrollment target (99% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Postural Orthostatic Tachycardia Syndrome appearing as the primary indexed condition, and to 4 interventions - of which Genetic Testing is the first listed.

NCT05344599 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.

Frequently Asked Questions

What is clinical trial NCT05344599 about?

NCT05344599 is a clinical study titled "Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome". Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women. The condition is characterized by a rapid increase in heart rate (HR) that occurs on standing, and chronic symptoms o...

What is the current status of trial NCT05344599?

This trial is currently active not recruiting. The enrollment target is 70 participants. The study started on 2022-01-19. Estimated completion is 2026-06-30.

What conditions does trial NCT05344599 study?

This clinical trial studies the following conditions: Postural Orthostatic Tachycardia Syndrome, Acute Hepatic Porphyria.

What interventions are being tested in trial NCT05344599?

The interventions under investigation include: Genetic Testing (DIAGNOSTIC_TEST), Autonomic Function Testing (DIAGNOSTIC_TEST), Urine Testing (DIAGNOSTIC_TEST), Blood laboratory Testing (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT05344599?

This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05344599 being conducted?

This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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