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NCT05212129 · ClinicalTrials.gov registry record · NA
Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome
A NA study of Postural Orthostatic Tachycardia Syndrome and Functional Gastrointestinal Disorders, sponsored by Medical College of Wisconsin.
- Recruiting
- Registry status
- NA
- Development phase
- 90
- Enrollment target
- 1
- Study location
NCT05212129 is a NA study of Postural Orthostatic Tachycardia Syndrome and Functional Gastrointestinal Disorders that is actively recruiting participants, run by Medical College of Wisconsin. The registered enrollment target is 90 participants, below the 9,236-participant average among 11 other Postural Orthostatic Tachycardia Syndrome trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05212129, a NA study of Postural Orthostatic Tachycardia Syndrome and Functional Gastrointestinal Disorders, is actively recruiting participants, sponsored by Medical College of Wisconsin.
- RECRUITING
- Registry status
- NA
- Development phase
- 90 participants
- Enrollment target
- 1
- Study location
Study Summary
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations. For unclear reasons, hEDS is associated with many gastrointestinal (GI) and autonomic nervous system (ANS) complaints such as postural orthostatic tachycardia syndrome (POTS). This study will address the clinical relationship between hEDS/Hypermobile Spectrum Disorders and autonomic regulation and see if there is a benefit of two forms of non-invasive vagal nerve stimulation therapies to reduce GI symptoms in hEDS and POTS. The study will also investigate plausible effects of these nerve stimulation therapies on gastric function and autonomic signaling.
Conditions Studied
Interventions
- DEVICE Percutaneous vagal nerve stimulation (pVNS) device
- OTHER Acoustic vagal nerve stimulation (aVNS) treatment
Study Locations (1)
Wisconsin
- Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2021-04-05 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05212129
The ClinicalTrials.gov registry entry for NCT05212129 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 9,236-participant average among 11 other Postural Orthostatic Tachycardia Syndrome trials with a reported enrollment target (99% lower). The listed sponsor is Medical College of Wisconsin, which has 447 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Postural Orthostatic Tachycardia Syndrome appearing as the primary indexed condition, and to 2 interventions - of which Percutaneous vagal nerve stimulation (pVNS) device is the first listed.
NCT05212129 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05212129 about?
NCT05212129 is a clinical study titled "Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome". Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations. For unclear reasons, hEDS is associated with many gastrointestinal (GI) and autonomic nervous system (ANS) complaints ...
What is the current status of trial NCT05212129?
This trial is currently recruiting. It is a NA study. The enrollment target is 90 participants. The study started on 2021-04-05. Estimated completion is 2026-12-31.
What conditions does trial NCT05212129 study?
This clinical trial studies the following conditions: Postural Orthostatic Tachycardia Syndrome, Functional Gastrointestinal Disorders, Autonomic Nervous System Disease, Autonomic Nervous System Imbalance, Hypermobile Ehlers-Danlos Syndrome.
What interventions are being tested in trial NCT05212129?
The interventions under investigation include: Percutaneous vagal nerve stimulation (pVNS) device (DEVICE), Acoustic vagal nerve stimulation (aVNS) treatment (OTHER).
Who is sponsoring clinical trial NCT05212129?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05212129 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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