Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Pelvic Organ Prolapse

Open-data reference.

PlainTrial home → About this data

41 US clinical trials · 8 currently recruiting

Active & Recent Trials

RECRUITING 1,000 participants

Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

Ethicon

NCT04829175
RECRUITING NA 288 participants

The AccelERate Trial

NICHD Pelvic Floor Disorders Network

NCT07218016
RECRUITING NA 182 participants

POMEGRANATE Trial: Comparing Reia Pessary Versus Standard of Care Pessary for Pelvic Organ Prolapse Treatment

Medstar Health Research Institute

NCT06634459
RECRUITING NA 112 participants

SORE Study: Sitz Baths After Urogynecologic Reconstruction

Yale University

NCT07215780
RECRUITING NA 110 participants

Sequence of Midurethral Sling Placement During Robotic Sacrocolpopexy

University of Alabama at Birmingham

NCT07008898
RECRUITING 106 participants

Centered Surgery - Preoperative Counseling and Patient Satisfaction

The Cleveland Clinic

NCT07471464
RECRUITING 100 participants

GYNEMESH PS Mesh Post Marketing Clinical Follow-Up Study

Ethicon

NCT04829058
RECRUITING 30 participants

Pessary Experience Study

University of Virginia

NCT06021769
ACTIVE NOT RECRUITING NA 420 participants

EASE: The Materna Prep Pivotal Study

Materna Medical

NCT03973281
ACTIVE NOT RECRUITING NA 142 participants

Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery

Brigham and Women's Hospital

NCT03522961
ACTIVE NOT RECRUITING NA 112 participants

SCP vs HUSLS for Pelvic Organ Prolapse Repair

Loma Linda University

NCT02800512
ACTIVE NOT RECRUITING 80 participants

Intraoperative Costs and Patient Perceptions in Sacrocolpopexy for Prolapse

Mayo Clinic

NCT04179955
ACTIVE NOT RECRUITING NA 60 participants

Platelet Rich Plasma as an Adjunct Therapy at the Time of Transvaginal Native Tissue Prolapse Surgery

University of Alabama at Birmingham

NCT05731284
ACTIVE NOT RECRUITING NA 53 participants

Clinical Investigation of the da Vinci Surgical System

Intuitive Surgical

NCT05682742
ACTIVE NOT RECRUITING NA 30 participants

Vaginal Orthosis Use After Vaginal Reconstructive Surgery

University of Alabama at Birmingham

NCT05812859
COMPLETED 316 participants

Comparison of 2 Lightweight Y-meshes After Laparoscopic Sacrocolpopexy

Atlantic Health System

NCT02248935
COMPLETED NA 285 participants

The Extended Operations And Pelvic Muscle Training In The Management Of Apical Support Loss Study

NICHD Pelvic Floor Disorders Network

NCT01166373
COMPLETED 210 participants

Race, Ethnicity, Socioeconomic Status and Prolapse-rElated Decisional ConflicT

Women and Infants Hospital of Rhode Island

NCT04977141
COMPLETED 202 participants

Predictors of Recovery Expectancy

Indiana University

NCT04274491
COMPLETED 158 participants

Validation of Transvaginal Tactile Imaging

Artann Laboratories

NCT01491334
COMPLETED Phase 4 154 participants

Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery

Halina M Zyczynski, MD

NCT02727322
COMPLETED 152 participants

Colpocleisis for Advanced Pelvic Organ Prolapse

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00271037
COMPLETED 132 participants

Predictors of Post Operative Morbidity in Older Women With Pelvic Organ Prolapse

University of Pennsylvania

NCT01967446
COMPLETED NA 114 participants

Pelvic Floor Disorder Assessment of Knowledge and Symptoms: an Educational Model in Spanish-Speaking Women

Johns Hopkins University

NCT04829721
COMPLETED NA 110 participants

Voiding Assessment Based on Minimum Spontaneous Void of 150 mL Compared to Retrograde Fill Method After Female Pelvic Floor Reconstructive Surgery

Yale University

NCT03539107
COMPLETED Phase 4 110 participants

Preoperative Gabapentin vs Placebo for Vaginal Prolapse Surgery

Joseph Kowalski

NCT05658887
COMPLETED 103 participants

Caregiver Support and Post-operative Convalescence

Icahn School of Medicine at Mount Sinai

NCT04897061
COMPLETED NA 100 participants

The Purpose of This Study is to Look at Pelvic Support Problems, Also Commonly Known as Pelvic Organ Prolapse

University of Oklahoma

NCT00964197
COMPLETED NA 94 participants

Impact of Level III Support Procedure on Enlarged Genital Hiatus After Minimally Invasive Sacrocolpopexy

University of Pittsburgh

NCT04480671
COMPLETED NA 84 participants

Abdominal Colpopexy: Comparison of Endoscopic Surgical Strategies

Loyola University

NCT01124916
COMPLETED NA 78 participants

Feasibility Study of the Reia Vaginal Pessary

Reia

NCT04508335
COMPLETED 74 participants

Axis™ Allograft Dermis for Female Pelvic Floor Repair: a Prospective Post Market Study

Coloplast A/S

NCT01541748
COMPLETED NA 72 participants

Pudendal Nerve Block in Vaginal Surgery

MetroHealth Medical Center

NCT04198714
COMPLETED Phase 3 66 participants

Lidocaine for Pessary Check Pain Reduction

University of South Florida

NCT05493735
COMPLETED NA 64 participants

Timing of Repeat Voiding Trials After Outpatient Pelvic Floor Surgery

The Cleveland Clinic

NCT03048682
COMPLETED Phase 3 63 participants

Effects of Preoperative Dexamethasone Study on QOL After Vaginal Reconstructive Surgery for POP

TriHealth

NCT02073734
COMPLETED 63 participants

EVeRLAST 2-Year Follow-Up

Duke University

NCT05542836
COMPLETED NA 58 participants

Prediction of Postsurgical Symptomatic Outcomes With Preoperative Pessary Use

Mayo Clinic

NCT02680145
COMPLETED NA 52 participants

Analysis of Procedural Times Using Colpassist for Robotic-Assisted Sacrocolpopexy; a Randomized Controlled Trial

University of North Carolina, Chapel Hill

NCT02367235
COMPLETED NA 51 participants

Perineorrhaphy Outcomes Related to Body Imagery

University of New Mexi

NCT02548858
COMPLETED 18 participants

Advanced Biomarker Assessment in Pelvic Organ Prolapse

Mayo Clinic

NCT03642054

Phase Distribution

PhaseTrial count
Phase 3 2
Phase 4 2

Top Sponsors

Mayo Clinic 3 trials
University of Alabama at Birmingham 3 trials
Ethicon 2 trials
NICHD Pelvic Floor Disorders Network 2 trials
The Cleveland Clinic 2 trials
Yale University 2 trials
Joseph Kowalski 1 trials
Halina M Zyczynski, MD 1 trials
Reia 1 trials
Artann Laboratories 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pelvic Organ Prolapse Trial Landscape

ClinicalTrials.gov lists 41 US studies indexed under Pelvic Organ Prolapse, and 8 of those are currently open to recruitment — roughly 20% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Pelvic Organ Prolapse shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Pelvic Organ Prolapse is led by Mayo Clinic with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 41 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pelvic Organ Prolapse?

PlainTrial tracks 41 US clinical trials for Pelvic Organ Prolapse, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pelvic Organ Prolapse?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related Guides

Related

Browse all → | Rankings →
Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Read our methodology — how this data is sourced, computed, and verified.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →