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NCT05074277 · ClinicalTrials.gov registry record · NA
Skeletal Response to Simulated Night Shift
A NA study of Osteoporosis and Circadian Rhythm Sleep Disorder, Shift Work Type, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05074277: Completed NA study of Osteoporosis and Circadian Rhythm Sleep Disorder, Shift Work Type, sponsored by University of Colorado, Denver.
NCT05074277 is a NA study of Osteoporosis and Circadian Rhythm Sleep Disorder, Shift Work Type that has completed, run by University of Colorado, Denver. The registered enrollment target is 20 participants, below the 1,546-participant average among 84 other Osteoporosis trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05074277, a NA study of Osteoporosis and Circadian Rhythm Sleep Disorder, Shift Work Type, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This small intervention study will determine if simulated short-term night shift work (NSW) negatively alters bone metabolism. The specific aim of the study is to determine if NSW acutely uncouples bone turnover markers (BTMs), if sympathetic tone is a mechanism for this disruption and if a resumption of a normal sleep/wake pattern reverses BTM uncoupling. Our hypothesis is that NSW will reversibly uncouple BTMs via increased sympathetic nervous system (SNS) tone.
Primary Outcome
Difference in change in propeptide of type 1 procollagen (P1NP, a bone formation marker) from baseline to day 11 between the control and simulated NSW groups.
Conditions Studied
Interventions
- BEHAVIORAL Simulated short term night shift work schedule
Study Locations (1)
Colorado
- CU Anschutz - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-02-08 |
| Est. Completion | 2025-12-18 |
| Phase | NA |
What the finished NCT05074277 record still lists
NCT05074277 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,546-participant average among 84 other Osteoporosis trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Osteoporosis appearing as the primary indexed condition, and to 1 intervention - of which Simulated short term night shift work schedule is the first listed.
NCT05074277 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT05074277 about?
NCT05074277 is a clinical study titled "Skeletal Response to Simulated Night Shift". This small intervention study will determine if simulated short-term night shift work (NSW) negatively alters bone metabolism. The specific aim of the study is to determine if NSW acutely uncouples bone turnover markers (BTMs), if sympathetic tone is a mechanism for this disruption and if a resumpti...
What is the current status of trial NCT05074277?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2022-02-08. Estimated completion is 2025-12-18.
What conditions does trial NCT05074277 study?
This clinical trial studies the following conditions: Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type.
What interventions are being tested in trial NCT05074277?
The interventions under investigation include: Simulated short term night shift work schedule (BEHAVIORAL).
Who is sponsoring clinical trial NCT05074277?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05074277 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoporosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05074277's enrollment target sits among peer trials
20 75th of 84 higher than 9 of 84 other Osteoporosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoporosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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