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Opioid Withdrawal clinical trials
4 of 10 indexed Opioid Withdrawal trials are currently recruiting.
10 US clinical trials · 4 currently recruiting
Opioid Withdrawal is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Spark Biomedical, running 2 of these trials.
The research picture
Opioid Withdrawal has 10 registered US clinical trials, 4 of them open to new participants right now, about 40% of the total.
- 4
- recruiting participants now
- 40%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Spark Biomedical
Active & Recent Trials
10 total, page 1 of 1
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
Medical University of South Carolina
NCT06442566
Understanding the Effects of Transcutaneous Auricular Neurostimulation for Treatment of Chronic Pain
The University of Texas Medical Branch, Galveston
NCT05555485
Assessing a Clinically-meaningful Opioid Withdrawal Phenotype
University of Maryland, Baltimore
NCT05027919
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
Spark Biomedical
NCT06487533
Sublingual Dexmedetomidine for Treating Opioid Withdrawal
New York State Psychiatric Institute
NCT05712707
Evaluating Buspirone to Treat Opioid Withdrawal
Johns Hopkins University
NCT05511909
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
BioXcel Therapeutics
NCT04470050
5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
Stanford University
NCT01549652
Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal
University of Pennsylvania
NCT04218240
Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
Spark Biomedical
NCT04075214
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Opioid Withdrawal Trial Landscape
10 indexed Opioid Withdrawal studies · 4 recruiting (40%).
Phase mix: 0 late (III/IV) vs 6 early (I/II).
Top sponsor: Spark Biomedical (2 trials), 8 others listed. 10 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Opioid Withdrawal?
PlainTrial tracks 10 US clinical trials for Opioid Withdrawal, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Opioid Withdrawal?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.