Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Opioid Withdrawal: early-phase trial registry
4 of 10 indexed Opioid Withdrawal trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,724 of 28,707 conditions by registered trial count.
10 US clinical trials · 4 currently recruiting · #1,724 of 28,707 conditions by registered trial count
Opioid Withdrawal: 10 US clinical trials tracked, 4 recruiting.
Opioid Withdrawal is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Spark Biomedical, running 2 of these trials.
Enrollment posture brief
Registry condition opioid-withdrawal
OPEN 4 | RECR 40% | LATE 0 | EARLY 6 | RANK #1724 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Acute Myeloid Leukemia (AML) (40% recruiting · 30 trials)
Opioid Withdrawal lists 4 open slots (40% of 10 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid Withdrawal on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid Withdrawal is recruiting below its size-band peers.
4 of 10 indexed trials (40%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Opioid Withdrawal research.
Spark Biomedical accounts for 2 of 10 trials (20%). 9 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid Withdrawal enrolment sits around 100 participants.
Median target enrolment is 100 among the 10 trials that report a genuine target (sentinel values excluded). 5 of those (50%) plan for fewer than 100 participants.
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Opioid Withdrawal research is mostly interventional.
9 interventional and 1 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
10 total, page 1 of 1
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
Medical University of South Carolina
NCT06442566
Understanding the Effects of Transcutaneous Auricular Neurostimulation for Treatment of Chronic Pain
The University of Texas Medical Branch, Galveston
NCT05555485
Assessing a Clinically-meaningful Opioid Withdrawal Phenotype
University of Maryland, Baltimore
NCT05027919
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
Spark Biomedical
NCT06487533
Sublingual Dexmedetomidine for Treating Opioid Withdrawal
New York State Psychiatric Institute
NCT05712707
Evaluating Buspirone to Treat Opioid Withdrawal
Johns Hopkins University
NCT05511909
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
BioXcel Therapeutics
NCT04470050
5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
Stanford University
NCT01549652
Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal
University of Pennsylvania
NCT04218240
Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
Spark Biomedical
NCT04075214
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid Withdrawal records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid Withdrawal trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid Withdrawal page
10 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Opioid Withdrawal trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Spark Biomedical sponsors the most Opioid Withdrawal trials on record, review their full trial history before evaluating a specific study. See Spark Biomedical's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid Withdrawal condition card totals 10 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.