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ClinicalTrials.gov 8 recruiting now official registry

Open Angle Glaucoma clinical trials

8 of 30 indexed Open Angle Glaucoma trials are currently recruiting.

30 US clinical trials · 8 currently recruiting

Open Angle Glaucoma is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Alcon Research, running 4 of these trials.

The research picture

Open Angle Glaucoma has 30 registered US clinical trials, 8 of them open to new participants right now, about 27% of the total.

8
recruiting participants now
27%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
4
top sponsor: Alcon Research
Phase 14Phase 22Phase 311Phase 44

Active & Recent Trials

30 total, page 1 of 1

RECRUITING 300 participants

Efficacy of Surgical Systems in Combination With Phacoemulsification: a Retrospective Analysis

Barnet Dulaney Perkins Eye Centers

NCT06953349

RECRUITING Phase 1 240 participants

A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes

Amneal Pharmaceuticals

NCT06267274

RECRUITING NA 129 participants

Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy

Sanoculis

NCT06313749

RECRUITING Phase 1 96 participants

AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension

AbbVie

NCT04499248

RECRUITING Phase 4 70 participants

Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost

Prairie Eye Center

NCT06883123

RECRUITING Phase 4 30 participants

24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients

Mayo Clinic

NCT07325240

RECRUITING Phase 4 20 participants

Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma

Jonathon Myers

NCT07228221

RECRUITING Phase 4 20 participants

Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use

University of Miami

NCT07217678

ACTIVE NOT RECRUITING Phase 3 489 participants

Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction

Alcon Research

NCT07082816

ACTIVE NOT RECRUITING Phase 3 455 participants

Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

AbbVie

NCT03891446

ACTIVE NOT RECRUITING NA 150 participants

STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma

New World Medical

NCT05280366

ACTIVE NOT RECRUITING Phase 1 36 participants

A Study of PER-001 in Participants With Open-Angle Glaucoma

Perfuse Therapeutics

NCT05822245

COMPLETED 2,597 participants

Comparative Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma

Agency for Healthcare Research and Quality (AHRQ)

NCT01645319

COMPLETED Phase 3 756 participants

Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension

Aerie Pharmaceuticals

NCT02207621

COMPLETED Phase 3 708 participants

Double-masked Study of Netarsudil (AR-13324) Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Aerie Pharmaceuticals

NCT02558374

COMPLETED Phase 3 696 participants

MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Nicox Ophthalmics

NCT04630808

COMPLETED Phase 3 682 participants

Evaluation of Safety and Efficacy of PDP-716

Sun Pharma Advanced Research Company Limited

NCT03450629

COMPLETED Phase 3 528 participants

A 12-week, Randomized, Double-masked, Parallel Group Comparison of Evening Dosing With Xalacom in Subjects With Glaucoma

Pfizer's Upjohn has merged with Mylan to form Viatris

NCT00277498

COMPLETED Phase 3 420 participants

Comparing the Safety and Efficacy of BOL-303259-X Ophthalmic Solution With Timolol Maleate Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Bausch & Lomb Incorporated

NCT01749930

COMPLETED 220 participants

18 Month Prospective Efficacy and Safety Study of Bimatoprost Intracameral Implant (DURYSTA)

Allergan

NCT04647214

COMPLETED Phase 2 201 participants

Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research

NCT00691717

COMPLETED Phase 3 161 participants

Evaluation of Safety of SPARC0913 in Open Angle Glaucoma or Ocular Hypertension

Sun Pharma Advanced Research Company Limited

NCT00945958

COMPLETED Phase 2 123 participants

A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)

Ono Pharmaceutical Co.

NCT02083289

COMPLETED Phase 3 81 participants

A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension

Alcon Research

NCT00465803

COMPLETED 59 participants

Determinants of Compliance With Glaucoma Therapy

University of Alabama at Birmingham

NCT00362622

COMPLETED 40 participants

Diurnal and Nocturnal Effect of Travatan With SofZia Preservative on Intraocular Pressure and Ocular Perfusion Pressure

University of Colorado, Denver

NCT01779778

COMPLETED 31 participants

Effects of Selective Laser Trabeculoplasty on Aqueous Humor Dynamics

University of Nebraska

NCT01342406

COMPLETED Phase 1 17 participants

Study of ANX007 in Participants With Primary Open-angle Glaucoma

Annexon

NCT04188015

COMPLETED NA 4 participants

Surgical Treatment of Refractory Open Angle Glaucoma

iScience Interventional Corporation

NCT01212861

COMPLETED Phase 3

Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-70

Alcon Research

NCT00047541

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 2
Phase 3 11
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Open Angle Glaucoma Trial Landscape

30 indexed Open Angle Glaucoma studies · 8 recruiting (27%).

Phase mix: 15 late (III/IV) vs 6 early (I/II).

Top sponsor: Alcon Research (4 trials), 9 others listed. 30 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Open Angle Glaucoma?

PlainTrial tracks 30 US clinical trials for Open Angle Glaucoma, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Open Angle Glaucoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.