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Open Angle Glaucoma clinical trials
8 of 30 indexed Open Angle Glaucoma trials are currently recruiting.
30 US clinical trials · 8 currently recruiting
Open Angle Glaucoma is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Alcon Research, running 4 of these trials.
The research picture
Open Angle Glaucoma has 30 registered US clinical trials, 8 of them open to new participants right now, about 27% of the total.
- 8
- recruiting participants now
- 27%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Alcon Research
Active & Recent Trials
30 total, page 1 of 1
Efficacy of Surgical Systems in Combination With Phacoemulsification: a Retrospective Analysis
Barnet Dulaney Perkins Eye Centers
NCT06953349
A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes
Amneal Pharmaceuticals
NCT06267274
Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
Sanoculis
NCT06313749
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
AbbVie
NCT04499248
Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost
Prairie Eye Center
NCT06883123
24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients
Mayo Clinic
NCT07325240
Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma
Jonathon Myers
NCT07228221
Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use
University of Miami
NCT07217678
Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction
Alcon Research
NCT07082816
Long-term Safety and Efficacy Extension Trial of Bimatoprost SR
AbbVie
NCT03891446
STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma
New World Medical
NCT05280366
A Study of PER-001 in Participants With Open-Angle Glaucoma
Perfuse Therapeutics
NCT05822245
Comparative Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma
Agency for Healthcare Research and Quality (AHRQ)
NCT01645319
Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension
Aerie Pharmaceuticals
NCT02207621
Double-masked Study of Netarsudil (AR-13324) Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension
Aerie Pharmaceuticals
NCT02558374
MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Nicox Ophthalmics
NCT04630808
Evaluation of Safety and Efficacy of PDP-716
Sun Pharma Advanced Research Company Limited
NCT03450629
A 12-week, Randomized, Double-masked, Parallel Group Comparison of Evening Dosing With Xalacom in Subjects With Glaucoma
Pfizer's Upjohn has merged with Mylan to form Viatris
NCT00277498
Comparing the Safety and Efficacy of BOL-303259-X Ophthalmic Solution With Timolol Maleate Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Bausch & Lomb Incorporated
NCT01749930
18 Month Prospective Efficacy and Safety Study of Bimatoprost Intracameral Implant (DURYSTA)
Allergan
NCT04647214
Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension
Alcon Research
NCT00691717
Evaluation of Safety of SPARC0913 in Open Angle Glaucoma or Ocular Hypertension
Sun Pharma Advanced Research Company Limited
NCT00945958
A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)
Ono Pharmaceutical Co.
NCT02083289
A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension
Alcon Research
NCT00465803
Determinants of Compliance With Glaucoma Therapy
University of Alabama at Birmingham
NCT00362622
Diurnal and Nocturnal Effect of Travatan With SofZia Preservative on Intraocular Pressure and Ocular Perfusion Pressure
University of Colorado, Denver
NCT01779778
Effects of Selective Laser Trabeculoplasty on Aqueous Humor Dynamics
University of Nebraska
NCT01342406
Study of ANX007 in Participants With Primary Open-angle Glaucoma
Annexon
NCT04188015
Surgical Treatment of Refractory Open Angle Glaucoma
iScience Interventional Corporation
NCT01212861
Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-70
Alcon Research
NCT00047541
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 2 |
| Phase 3 | 11 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Open Angle Glaucoma Trial Landscape
30 indexed Open Angle Glaucoma studies · 8 recruiting (27%).
Phase mix: 15 late (III/IV) vs 6 early (I/II).
Top sponsor: Alcon Research (4 trials), 9 others listed. 30 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Open Angle Glaucoma?
PlainTrial tracks 30 US clinical trials for Open Angle Glaucoma, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Open Angle Glaucoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.