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ACTIVE NOT RECRUITING Phase 3

Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction

NCT07082816 · View on ClinicalTrials.gov ↗

Study Summary

This study is designed to see how safe and effective a new eye drop, called Reformulated PG324, is for lowering eye pressure in people with open-angle glaucoma (OAG) or ocular hypertension (OHT).

Interventions

  • DRUG Netarsudil 0.01%/latanoprost 0.005% ophthalmic solution
  • DRUG Netarsudil 0.02%/latanoprost 0.005% ophthalmic solution

Study Locations (20)

Florida

  • Central Florida Eye Specialists — DeLand
  • Glaucoma Specialists of South Florida — Delray Beach
  • East Coast Institute for Research, LLC — Jacksonville
  • Central Florida Eye Associates — Lakeland
  • The Eye Institute of West Florida — Largo
  • Lee Shettle Eye — Largo

California

  • Orange County Ophthalmology Medical Group — Garden Grove
  • United Medical Research Institute — Inglewood
  • Eye Research Foundation — Newport Beach
  • North Bay Eye Associates — Petaluma
  • Sacramento Eye Consultants — Sacramento

Georgia

  • North Georgia Eye Associates — Gainesville
  • Coastal Research Associates — Roswell

Alabama

  • Trinity Research Group — Dothan

Arizona

  • Eye Doctors of Arizona — Phoenix

Kansas

  • Kannarr Eye Care LLC — Pittsburg

Massachusetts

  • NorthEast Eye Research Associates, LLC — Westborough

Mississippi

  • Coldwater Vision Research — Coldwater

Trial Details

FieldValue
Enrollment Target 489 participants
Start Date 2025-09-02
Est. Completion 2026-05
Phase Phase 3

Sponsor

Alcon Research

111 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07082816

The ClinicalTrials.gov registry entry for NCT07082816 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 489 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alcon Research, which has 111 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Ocular Hypertension appearing as the primary indexed condition, and to 2 interventions — of which Netarsudil 0.01%/latanoprost 0.005% ophthalmic solution is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07082816 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07082816 about?

NCT07082816 is a clinical study titled "Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction". This study is designed to see how safe and effective a new eye drop, called Reformulated PG324, is for lowering eye pressure in people with open-angle glaucoma (OAG) or ocular hypertension (OHT).

What is the current status of trial NCT07082816?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 489 participants. The study started on 2025-09-02. Estimated completion is 2026-05.

What conditions does trial NCT07082816 study?

This clinical trial studies the following conditions: Ocular Hypertension, Open Angle Glaucoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07082816?

The interventions under investigation include: Netarsudil 0.01%/latanoprost 0.005% ophthalmic solution (DRUG), Netarsudil 0.02%/latanoprost 0.005% ophthalmic solution (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07082816?

This trial is sponsored by Alcon Research, which has 111 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07082816 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial