Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension

NCT04499248 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participants with open-angle glaucoma or ocular hypertension

Interventions

  • DRUG AGN-193408 SR
  • OTHER Lumigan
  • OTHER Sham Administration
  • OTHER Lumigan Vehicle

Study Locations (20)

California

  • Global Research Management /ID# 241699 — Glendale
  • United Medical Research Institute /ID# 241701 — Inglewood
  • Lakeside Vision Center /ID# 241698 — Irvine
  • The Eye Research Foundation /ID# 234528 — Newport Beach
  • Sacramento Eye Consultants /ID# 241697 — Sacramento
  • Premiere Practice Management LLC /ID# 235957 — Torrance
  • Wolstan & Goldberg Eye Associates /ID# 241700 — Torrance

Florida

  • Brandon Eye Associates - Brandon /ID# 276600 — Brandon
  • Nature Coast Clinical Research - Crystal River /ID# 237781 — Crystal River
  • Advanced Research, LLC /ID# 276987 — Deerfield Beach
  • University of Florida Health Ophthalmology - Jacksonville /ID# 243122 — Jacksonville
  • East Florida Eye Institute /ID# 235762 — Stuart
  • Logan Ophthalmic Research Inc. /ID# 252087 — Tamarac

Georgia

  • Coastal Research Associates /ID# 234649 — Roswell
  • Thomas Eye Group PC /ID# 266775 — Sandy Springs

Indiana

  • Midwest Medical Advisors Inc /ID# 235845 — Carmel
  • Indiana University - Glick Eye Institute /ID# 235887 — Indianapolis

Arizona

  • Horizon Eye Specialists & Lasik Center - Sun City /ID# 252153 — Sun City

Connecticut

  • Connecticut Eye Consultants P.C. /ID# 235862 — Danbury

Illinois

  • University of Illinois Hospital and Health Sciences System /ID# 253630 — Chicago

Trial Details

FieldValue
Enrollment Target 96 participants
Start Date 2020-11-16
Est. Completion 2029-02
Phase Phase 1

Sponsor

AbbVie

603 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04499248

The ClinicalTrials.gov registry entry for NCT04499248 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 96 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie, which has 603 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Ocular Hypertension appearing as the primary indexed condition, and to 4 interventions — of which AGN-193408 SR is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04499248 reports 20 study locations spanning 7 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04499248 about?

NCT04499248 is a clinical study titled "AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension". This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participants with open-angle glaucoma or ocular hypertension

What is the current status of trial NCT04499248?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 96 participants. The study started on 2020-11-16. Estimated completion is 2029-02.

What conditions does trial NCT04499248 study?

This clinical trial studies the following conditions: Ocular Hypertension, Open-angle Glaucoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04499248?

The interventions under investigation include: AGN-193408 SR (DRUG), Lumigan (OTHER), Sham Administration (OTHER), Lumigan Vehicle (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04499248?

This trial is sponsored by AbbVie, which has 603 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04499248 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial