Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06883123 · ClinicalTrials.gov registry record · Phase 4
Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost
A Phase 4 study of Open Angle Glaucoma, sponsored by Prairie Eye Center.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT06883123: Recruiting Phase 4 study of Open Angle Glaucoma, sponsored by Prairie Eye Center.
NCT06883123 is a Phase 4 study of Open Angle Glaucoma that is actively recruiting participants, run by Prairie Eye Center. The registered enrollment target is 70 participants, below the 332-participant average among 28 other Open Angle Glaucoma trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06883123, a Phase 4 study of Open Angle Glaucoma, is actively recruiting participants, sponsored by Prairie Eye Center.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
A randomized, multi-site, parallel-group, prospective study of patients who are adults with a diagnosis of mild to moderate open-angle glaucoma (OAG), currently on an on-label use of combination topical medication of Cosopt and Latanoprost for a minimum of 1 month.
Primary Outcome
Mean diurnal IOP is determined as the average IOP measured at 8:30am, 12:00pm and 3:30pm
Conditions Studied
Interventions
- DRUG Latanoprost 0.005% Ophthalmic Solution
- DRUG Simbrinza 0.2%-1% Ophthalmic Suspension
- DRUG Rocklatan 0.02%-0.005% Ophthalmic Solution
- DRUG Cosopt PF 2%-0.5% Ophthalmic Solution
Study Locations (1)
Illinois
- Prairie Eye Center - Springfield
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2025-05-14 |
| Est. Completion | 2026-04-01 |
| Phase | Phase 4 |
What NCT06883123 shows while recruiting
NCT06883123 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 332-participant average among 28 other Open Angle Glaucoma trials with a reported enrollment target (79% lower).
The record links to 1 condition, with Open Angle Glaucoma appearing as the primary indexed condition, and to 4 interventions - of which Latanoprost 0.005% Ophthalmic Solution is the first listed.
NCT06883123 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06883123 about?
NCT06883123 is a clinical study titled "Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost". A randomized, multi-site, parallel-group, prospective study of patients who are adults with a diagnosis of mild to moderate open-angle glaucoma (OAG), currently on an on-label use of combination topical medication of Cosopt and Latanoprost for a minimum of 1 month.
What is the current status of trial NCT06883123?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 70 participants. The study started on 2025-05-14. Estimated completion is 2026-04-01.
What conditions does trial NCT06883123 study?
This clinical trial studies the following conditions: Open Angle Glaucoma.
What interventions are being tested in trial NCT06883123?
The interventions under investigation include: Latanoprost 0.005% Ophthalmic Solution (DRUG), Simbrinza 0.2%-1% Ophthalmic Suspension (DRUG), Rocklatan 0.02%-0.005% Ophthalmic Solution (DRUG), Cosopt PF 2%-0.5% Ophthalmic Solution (DRUG).
Who is sponsoring clinical trial NCT06883123?
This trial is sponsored by Prairie Eye Center, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06883123 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Open Angle Glaucoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06883123's enrollment target sits among peer trials
70 20th of 28 higher than 9 of 28 other Open Angle Glaucoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Open Angle Glaucoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients
RECRUITING · Phase 4
-
Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma
RECRUITING · Phase 4
-
Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use
RECRUITING · Phase 4
-
Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
RECRUITING · NA
-
A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes
RECRUITING · Phase 1
-
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00969111 · 70 participants · NA
Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy
- NCT01712620 · 70 participants · Phase 2
Spironolactone for Pulmonary Arterial Hypertension
- NCT02143830 · 70 participants · Phase 2
HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy
- NCT02601339 · 70 participants
NIRS Monitoring in Premature Infants
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI