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MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension
NCT04630808 · View on ClinicalTrials.gov ↗
Study Summary
The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma. Subjects will be randomized in a 1:1 ratio to NCX 470 0.1% or to latanoprost 0.005% to be administered to both eyes once daily in the evening for up to 12 months.
Conditions Studied
Interventions
- DRUG NCX 470 0.1%
- DRUG Latanoprost 0.005%
Study Locations (20)
California
- Nicox Clinical Site — Burbank
- Nicox Clinical Site — Garden Grove
- Nicox Clinical Site — Huntington Beach
- Nicox Clinical Site — La Jolla
- Nicox Clinical Site — Murrieta
- Nicox Clinical Site — Newport Beach
- Nicox Clinical Site — Pasadena
- Nicox Clinical Site — Petaluma
- Nicox Clinical Site — Redlands
- Nicox Clinical Site — San Francisco
Florida
- Nicox Clinical Site — Boynton Beach
- Nicox Clinical Site — Delray Beach
- Nicox Clinical Site — Fort Lauderdale
- Nicox Clinical Site — Fort Myers
- Nicox Clinical Site — Jacksonville
- Nicox Clinical Site — Jupiter
Arizona
- Nicox Clinical Site — Chandler
- Nicox Clinical Site — Phoenix
Alabama
- Nicox Clinical Site — Dothan
Connecticut
- Nicox Clinical Site — Danbury
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 696 participants |
| Start Date | 2020-11-09 |
| Est. Completion | 2025-06-25 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04630808
The ClinicalTrials.gov registry entry for NCT04630808 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 696 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nicox Ophthalmics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Ocular Hypertension appearing as the primary indexed condition, and to 2 interventions — of which NCX 470 0.1% is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04630808 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04630808 about?
NCT04630808 is a clinical study titled "MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension". The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma. Subjects will be randomized in a 1:1 ratio to NCX 470 0.1% or to latanoprost 0.005% to be admi...
What is the current status of trial NCT04630808?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 696 participants. The study started on 2020-11-09. Estimated completion is 2025-06-25.
What conditions does trial NCT04630808 study?
This clinical trial studies the following conditions: Ocular Hypertension, Open Angle Glaucoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04630808?
The interventions under investigation include: NCX 470 0.1% (DRUG), Latanoprost 0.005% (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04630808?
This trial is sponsored by Nicox Ophthalmics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04630808 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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