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NCT04244162 · ClinicalTrials.gov registry record
Postoperative Neurocognitive Disorders
A clinical trial of Obstructive Sleep Apnea and Neurocognitive Disorders, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- 32
- Enrollment target
- 1
- Study location
NCT04244162: Completed study of Obstructive Sleep Apnea and Neurocognitive Disorders, sponsored by Massachusetts General Hospital.
NCT04244162 is a study of Obstructive Sleep Apnea and Neurocognitive Disorders that has completed, run by Massachusetts General Hospital. The registered enrollment target is 32 participants, below the 221-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04244162, a study of Obstructive Sleep Apnea and Neurocognitive Disorders, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine the mechanisms of brain injury contributing to postoperative neurocognitive disorders (PNCD) in an at-risk population (obstructive sleep apnea (OSA)) undergoing surgery. The investigators will enroll 50 OSA patients scheduled for surgery. All patients will have a brain scan (fMRI) within five days before surgery and two days and six months after surgery. During this visit cognitive function will be assessed using the Wide Range Assessment of Memory and Learning (WRAML2) and Montreal Cognitive Assessment (MoCA) tests. Patients will also be asked to participate in a blood draw during the first 2 visits for fMRI (within five days of surgery and two days after surgery). The Confusion Assessment Method (CAM-S) test, will be used to examine postoperative delirium.
Primary Outcome
Montreal Cognitive Assessment (MoCA) test
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Brain Imaging
- DIAGNOSTIC_TEST Cognitive testing
- DIAGNOSTIC_TEST Blood Biomarkers
Study Locations (1)
California
- Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2020-12-12 |
| Est. Completion | 2025-08-31 |
What the finished NCT04244162 record still lists
NCT04244162 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 221-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (86% lower).
The record links to 2 conditions, with Obstructive Sleep Apnea appearing as the primary indexed condition, and to 3 interventions - of which Brain Imaging is the first listed.
NCT04244162 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04244162 about?
NCT04244162 is a clinical study titled "Postoperative Neurocognitive Disorders". The purpose of this study is to examine the mechanisms of brain injury contributing to postoperative neurocognitive disorders (PNCD) in an at-risk population (obstructive sleep apnea (OSA)) undergoing surgery. The investigators will enroll 50 OSA patients scheduled for surgery. All patients will hav...
What is the current status of trial NCT04244162?
This trial is currently completed. The enrollment target is 32 participants. The study started on 2020-12-12. Estimated completion is 2025-08-31.
What conditions does trial NCT04244162 study?
This clinical trial studies the following conditions: Obstructive Sleep Apnea, Neurocognitive Disorders.
What interventions are being tested in trial NCT04244162?
The interventions under investigation include: Brain Imaging (DIAGNOSTIC_TEST), Cognitive testing (DIAGNOSTIC_TEST), Blood Biomarkers (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04244162?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04244162 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04244162's enrollment target sits among peer trials
32 127th of 155 higher than 29 of 155 other Obstructive Sleep Apnea trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obstructive Sleep Apnea trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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