Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
NAFLD: early-phase trial registry
9 of 27 indexed NAFLD trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #598 of 28,707 conditions by registered trial count.
27 US clinical trials · 9 currently recruiting · #598 of 28,707 conditions by registered trial count
NAFLD: 27 US clinical trials tracked, 9 recruiting.
NAFLD is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 3 of these trials.
Enrollment posture brief
Registry condition nafld
OPEN 9 | RECR 33% | LATE 1 | EARLY 9 | RANK #598 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Adherence, Treatment (33% recruiting · 6 trials)
NAFLD lists 9 open slots (33% of 27 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for NAFLD on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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NAFLD is recruiting below its size-band peers.
9 of 27 indexed trials (33.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of NAFLD trials is spread across many organizations.
Yale University accounts for 3 of 27 trials (11.1%). 21 distinct sponsors appear on at least one study for this condition label.
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Typical NAFLD enrolment sits around 72 participants.
Median target enrolment is 72 among the 27 trials that report a genuine target (sentinel values excluded). 16 of those (59.3%) plan for fewer than 100 participants.
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NAFLD splits between interventional and observational designs.
18 interventional and 9 observational studies make up this index (66.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
27 total, page 1 of 1
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
Yale University
NCT04634643
Reversal of Lipid-Induced Insulin Resistance
Yale University
NCT02193295
Androgens and NAFLD Longitudinal Cohort Study
University of California, San Francisco
NCT06124261
Digoxin In NASH (CODIN)
Yale University
NCT06588699
Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study)
University of Colorado, Denver
NCT05935826
Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant
Virginia Commonwealth University
NCT05424003
Bicalutamide Therapy in Young Women With NAFLD and PCOS
University of California, San Francisco
NCT05979389
NASH AMPK Exercise Dosing (AMPED) Trial
Milton S. Hershey Medical Center
NCT04987879
NAFLD Clinical Care Pathway
VA Office of Research and Development
NCT06671886
Prevalence and Predictors of Hepatic Steatosis in Persons Living With HIV
University of California, San Francisco
NCT04795219
LITMUS Imaging Study
University of Oxford
NCT05479721
Nonalcoholic Fatty Liver Disease in HIV Database
Johns Hopkins University
NCT05023044
A Study to Evaluate the Efficacy and Safety of Rencofilstat in Subjects With NASH and Advanced Liver Fibrosis
Hepion Pharmaceuticals
NCT05402371
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)
Merck Sharp & Dohme
NCT06465186
A Study to Evaluate DD01 in Overweight/Obese Subjects With MASLD/MASH
Neuraly
NCT06410924
Accurate Point of Care Liver Disease Diagnostics
University of California, San Diego
NCT05986916
An Imaging-based Quantitative Biomarker Assay for NAFLD in Children
University of Wisconsin, Madison
NCT06354491
The Effects of Glucagon on Hepatic Metabolism
Adrian Vella
NCT05500586
Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD
University of Iowa
NCT04861571
Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05669677
Quantifying Body Composition and Liver Disease in Children Using Free-Breathing MRI and MRE
University of California, Los Angeles
NCT04591106
Healthy Eating Through Reduction Of Excess Sugar
University of Southern California
NCT02948647
Safety Tolerability, and PK of RYI-018 After Repeat Dosing in Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)
Bird Rock Bio
NCT03261739
The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)
Fred Hutchinson Cancer Center
NCT02663544
Treating PCOS With Semaglutide vs Active Lifestyle Intervention
University of Colorado, Denver
NCT03919929
Healthy Liver - Healthy Brain
University of Texas at Austin
NCT05216796
Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease
Virginia Commonwealth University
NCT02132780
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 6 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on NAFLD records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on NAFLD trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this NAFLD page
27 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 NAFLD trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most NAFLD trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This NAFLD condition card totals 27 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.