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ACTIVE NOT RECRUITING Phase 2

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

NCT06465186 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat MASH.The goals of this study are to learn: * If efinopegdutide can lower the amount of fat, inflammation, and scarring (fibrosis) in the liver * About the safety of efinopegdutide and how well people tolerate it

Interventions

  • COMBINATION_PRODUCT Placebo
  • COMBINATION_PRODUCT Efinopegdutide

Study Locations (20)

Arizona

  • The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149) — Chandler
  • Arizona Clinical Trials ( Site 0158) — Flagstaff
  • The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0120) — Peoria
  • The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 0111) — Tucson

Florida

  • Synergy Healthcare ( Site 0118) — Bradenton
  • Homestead Associates in Research, Inc. ( Site 0139) — Homestead
  • Florida Research Institute ( Site 0116) — Lakewood Rch
  • Floridian Clinical Research, LLC ( Site 0109) — Miami Lakes

California

  • California Liver Research Institute ( Site 0113) — Pasadena
  • Acclaim Clinical Research ( Site 0137) — San Diego
  • Velocity Clinical Research, Panorama City ( Site 0124) — Van Nuys

Louisiana

  • Delta Research Partners ( Site 0160) — Bastrop
  • Louisiana Research Center ( Site 0161) — Shreveport

Maryland

  • Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 0130) — Glen Burnie
  • Velocity Clinical Research Rockville ( Site 0143) — Rockville

Nevada

  • The Machuca Foundation ( Site 0115) — Las Vegas
  • Excel Clinical Research, LLC ( Site 0101) — Las Vegas

Colorado

  • Rocky Mountain Gastroenterology ( Site 0127) — Littleton

Georgia

  • Southeast Clinical Research Center ( Site 0119) — Dalton

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2024-07-12
Est. Completion 2026-08-06
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06465186

The ClinicalTrials.gov registry entry for NCT06465186 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with NAFLD appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06465186 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Arizona, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06465186 about?

NCT06465186 is a clinical study titled "A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)". Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat...

What is the current status of trial NCT06465186?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2024-07-12. Estimated completion is 2026-08-06.

What conditions does trial NCT06465186 study?

This clinical trial studies the following conditions: NAFLD, Nonalcoholic Steatohepatitis, Non-alcoholic Fatty Liver Disease, Metabolic Dysfunction-associated Steatohepatitis, Metabolic Dysfunction-associated Steatotic Liver Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06465186?

The interventions under investigation include: Placebo (COMBINATION_PRODUCT), Efinopegdutide (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06465186?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06465186 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial