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NCT03919929 · ClinicalTrials.gov registry record · Phase 2
Treating PCOS With Semaglutide vs Active Lifestyle Intervention
A Phase 2 study of NAFLD and Adolescent Obesity, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT03919929: Completed Phase 2 study of NAFLD and Adolescent Obesity, sponsored by University of Colorado, Denver.
NCT03919929 is a Phase 2 study of NAFLD and Adolescent Obesity that has completed, run by University of Colorado, Denver. The registered enrollment target is 60 participants, below the 163-participant average among 26 other NAFLD trials with a reported enrollment target (63% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03919929, a Phase 2 study of NAFLD and Adolescent Obesity, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Girls with obesity and polycystic ovarian syndrome will receive either glucagon like peptide-1 receptor agonist therapy or a dietary intervention for 12 weeks to decrease the metabolic syndrome, in particular to lower hepatic fat and improve insulin sensitivity.
Primary Outcome
Change from baseline in presence/severity of hepatic fat fraction will be measured with MRI, and calculated via the Dixon method as the proton density hepatic fat fraction, which ranges from 0-75%. A negative value means a decrease in liver fat, and a positive value means an increase in liver fat.
Conditions Studied
Interventions
- DRUG Semaglutide 3mg and 7mg [Rybelsus]
- OTHER Weight loss diet
Study Locations (1)
Colorado
- University of Colorado Anshutz Medical Campus/Children's Hospital Colorado - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2019-05-03 |
| Est. Completion | 2023-10-03 |
| Phase | Phase 2 |
What the finished NCT03919929 record still lists
NCT03919929 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 163-participant average among 26 other NAFLD trials with a reported enrollment target (63% lower).
The record links to 3 conditions, with NAFLD appearing as the primary indexed condition, and to 2 interventions - of which Semaglutide 3mg and 7mg [Rybelsus] is the first listed.
NCT03919929 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT03919929 about?
NCT03919929 is a clinical study titled "Treating PCOS With Semaglutide vs Active Lifestyle Intervention". Girls with obesity and polycystic ovarian syndrome will receive either glucagon like peptide-1 receptor agonist therapy or a dietary intervention for 12 weeks to decrease the metabolic syndrome, in particular to lower hepatic fat and improve insulin sensitivity.
What is the current status of trial NCT03919929?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2019-05-03. Estimated completion is 2023-10-03.
What conditions does trial NCT03919929 study?
This clinical trial studies the following conditions: NAFLD, Adolescent Obesity, PCOS.
What interventions are being tested in trial NCT03919929?
The interventions under investigation include: Semaglutide 3mg and 7mg [Rybelsus] (DRUG), Weight loss diet (OTHER).
Who is sponsoring clinical trial NCT03919929?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03919929 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for NAFLD
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03919929's enrollment target sits among peer trials
60 16th of 26 higher than 11 of 26 other NAFLD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NAFLD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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