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NCT06588699 · ClinicalTrials.gov registry record · Phase 2
Digoxin In NASH (CODIN)
A Phase 2 study of NAFLD and NASH, sponsored by Yale University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 144
- Enrollment target
- 2
- Study locations
NCT06588699 is a Phase 2 study of NAFLD and NASH that is actively recruiting participants, run by Yale University. The registered enrollment target is 144 participants, below the 160-participant average among 26 other NAFLD trials with a reported enrollment target (10% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT06588699, a Phase 2 study of NAFLD and NASH, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 144 participants
- Enrollment target
- 2
- Study locations
Study Summary
Nonalcoholic steatohepatitis (NASH) is a severe subtype of nonalcoholic fatty liver disease (NAFLD) which affects 1 in 3 Americans. The mainstay of treatment for NASH, which was recently renamed metabolic associated steatohepatitis (MASH), involves lifestyle interventions to promote weight loss and to treat comorbidities such as hypertension, hyperlipidemia, and diabetes mellitus. There is thus, a substantial unmet need for pharmacological therapies that are effective for treatment of NASH, especially in those with fibrosis which is the main predictor of disease progression and mortality among NASH patients. The repurposing of presently available drugs would help expedite the search for agents effective in treating NASH. The cardiac glycoside digoxin is currently used in the management of heart failure and supraventricular tachyarrhythmias. The investigators and other groups have demonstrated that digoxin protects the liver from various forms of acute and chronic liver injury. The investigators preliminary data in healthy human subject indicate an immunomodulatory effect of low dose oral digoxin with no adverse side effects. This study proposes to demonstrate the clinical benefits of digoxin on NASH and on liver fibrosis, thus supporting the repurposing of digoxin as treatment for NASH.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Digoxin
Study Locations (2)
Connecticut
- Yale New Haven Health - New Haven
- Yale New Haven Hospital - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 144 participants |
| Start Date | 2025-06-05 |
| Est. Completion | 2029-01 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06588699
The ClinicalTrials.gov registry entry for NCT06588699 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 144 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 160-participant average among 26 other NAFLD trials with a reported enrollment target (10% lower). The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 8 conditions, with NAFLD appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06588699 reports 2 study locations spanning 1 distinct geographic area - top geographies include Connecticut.
Frequently Asked Questions
What is clinical trial NCT06588699 about?
NCT06588699 is a clinical study titled "Digoxin In NASH (CODIN)". Nonalcoholic steatohepatitis (NASH) is a severe subtype of nonalcoholic fatty liver disease (NAFLD) which affects 1 in 3 Americans. The mainstay of treatment for NASH, which was recently renamed metabolic associated steatohepatitis (MASH), involves lifestyle interventions to promote weight loss and ...
What is the current status of trial NCT06588699?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 144 participants. The study started on 2025-06-05. Estimated completion is 2029-01.
What conditions does trial NCT06588699 study?
This clinical trial studies the following conditions: NAFLD, NASH, MASLD, MASH, MASH - Metabolic Dysfunction-Associated Steatohepatitis.
What interventions are being tested in trial NCT06588699?
The interventions under investigation include: Placebo (DRUG), Digoxin (DRUG).
Who is sponsoring clinical trial NCT06588699?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06588699 being conducted?
This trial has 2 study locations across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.