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2026 data Public-data reference. official source

Myeloproliferative Neoplasm

Open-data reference.

41 US clinical trials · 20 currently recruiting

Active & Recent Trials

RECRUITING NA 400 participants

Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and Care

University of Miami

NCT05745285

RECRUITING Phase 2 216 participants

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

City of Hope Medical Center

NCT06059391

RECRUITING Phase 2 120 participants

Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

Fred Hutchinson Cancer Center

NCT03970096

RECRUITING Phase 2 100 participants

Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers

M.D. Anderson Cancer Center

NCT03589729

RECRUITING Phase 1 96 participants

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

M.D. Anderson Cancer Center

NCT03471260

RECRUITING NA 88 participants

Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant

University of Nebraska

NCT04898790

RECRUITING Phase 2 70 participants

Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms

H. Lee Moffitt Cancer Center and Research Institute

NCT05732961

RECRUITING Phase 1 58 participants

Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

M.D. Anderson Cancer Center

NCT03630991

RECRUITING Phase 1 58 participants

Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations

M.D. Anderson Cancer Center

NCT04493138

RECRUITING Phase 2 54 participants

Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases

Fred Hutchinson Cancer Center

NCT06013423

RECRUITING Phase 1 50 participants

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

Dana-Farber Cancer Institute

NCT04024761

RECRUITING 35 participants

Evaluation of the Pathobiology of CALR-mutated MPN Cells

Wake Forest University Health Sciences

NCT06480591

RECRUITING Phase 2 35 participants

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

City of Hope Medical Center

NCT06815003

RECRUITING 30 participants

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

Children's Hospital Medical Center, Cincinnati

NCT06131801

RECRUITING Phase 2 30 participants

CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04493164

RECRUITING Phase 1 30 participants

Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms

Fred Hutchinson Cancer Center

NCT06034470

RECRUITING Phase 1 27 participants

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

University of California, Irvine

NCT05123365

RECRUITING Phase 2 25 participants

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

University of Washington

NCT04282187

RECRUITING NA 20 participants

Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia

Case Comprehensive Cancer Center

NCT06421155

RECRUITING Phase 1 15 participants

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT06138587

ACTIVE NOT RECRUITING Phase 2 313 participants

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

Center for International Blood and Marrow Transplant Research

NCT06001385

ACTIVE NOT RECRUITING Phase 3 280 participants

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

Children's Oncology Group

NCT02521493

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN

AbbVie

NCT03386513

ACTIVE NOT RECRUITING Phase 1 140 participants

Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms

Incyte Corporation

NCT04279847

ACTIVE NOT RECRUITING Phase 2 132 participants

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm

National Cancer Institute (NCI)

NCT05600894

ACTIVE NOT RECRUITING 100 participants

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

Massachusetts General Hospital

NCT04902833

ACTIVE NOT RECRUITING Phase 1 85 participants

A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm

AbbVie

NCT04041050

ACTIVE NOT RECRUITING Phase 2 50 participants

Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes

National Cancer Institute (NCI)

NCT04802161

ACTIVE NOT RECRUITING Phase 1 35 participants

Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

Roswell Park Cancer Institute

NCT03192397

ACTIVE NOT RECRUITING NA 30 participants

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Ohio State University Comprehensive Cancer Center

NCT05972577

ACTIVE NOT RECRUITING Phase 2 25 participants

Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL)

H. Lee Moffitt Cancer Center and Research Institute

NCT05177211

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

ACTIVE NOT RECRUITING Phase 1 16 participants

Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms

Jacqueline Garcia, MD

NCT05455294

COMPLETED 119 participants

Collect and Assess Tissue Samples From Subjects With Hematologic Malignancy

Notable Labs

NCT04014764

COMPLETED Phase 2 73 participants

Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer

Fred Hutchinson Cancer Center

NCT00723099

COMPLETED Phase 1 71 participants

Ipilimumab or Nivolumab in Treating Patients With Relapsed Hematologic Malignancies After Donor Stem Cell Transplant

National Cancer Institute (NCI)

NCT01822509

COMPLETED Phase 1 50 participants

Pomalidomide After Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

National Cancer Institute (NCI)

NCT02029950

COMPLETED NA 47 participants

A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors

University of California, San Francis

NCT04605211

COMPLETED NA 40 participants

Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

University of Virginia

NCT04629430

COMPLETED Phase 2 18 participants

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Robert Lowsky

NCT02424968

COMPLETED NA 12 participants

Decitabine and Cytarabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia, High Risk Myelodysplastic Syndrome, or Myeloproliferative Neoplasm

University of Washington

NCT02121418

Phase Distribution

PhaseTrial count
Early Phase 1 14
Phase 2 15
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myeloproliferative Neoplasm Trial Landscape

ClinicalTrials.gov lists 41 US studies indexed under Myeloproliferative Neoplasm, and 20 of those are currently open to recruitment — roughly 49% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Myeloproliferative Neoplasm shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 29 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Myeloproliferative Neoplasm is led by M.D. Anderson Cancer Center with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 41 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myeloproliferative Neoplasm?

PlainTrial tracks 41 US clinical trials for Myeloproliferative Neoplasm, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myeloproliferative Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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