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NCT03589729 · ClinicalTrials.gov registry record · Phase 2
Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers
A Phase 2 study of Acute Myeloid Leukemia and Myeloproliferative Neoplasm, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT03589729: Recruiting Phase 2 study of Acute Myeloid Leukemia and Myeloproliferative Neoplasm, sponsored by M.D. Anderson Cancer Center.
NCT03589729 is a Phase 2 study of Acute Myeloid Leukemia and Myeloproliferative Neoplasm that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 100 participants, below the 116-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (14% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03589729, a Phase 2 study of Acute Myeloid Leukemia and Myeloproliferative Neoplasm, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase II trial studies how well dexrazoxane hydrochloride works in preventing heart-related side effects of chemotherapy in participants with blood cancers, such as acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia, and myeloproliferative neoplasms. Chemoprotective drugs, such as dexrazoxane hydrochloride, may protect the heart from the side effects of drugs used in chemotherapy, such as cladribine, idarubicin, cytarabine, and gemtuzumab ozogamicin, in participants with blood cancers.
Primary Outcome
Will assess a decrease in LVEF of 10 percent from baseline or decrease in LVEF below the normal limit of 50% during treatment with dexrazoxane hydrochloride combined with cladribine, idarubicin, cytarabine, and gemtuzumab ozogamicin.
Conditions Studied
Interventions
- DRUG Cladribine
- DRUG Gemtuzumab Ozogamicin
- DRUG Cytarabine
- DRUG Idarubicin
- DRUG Dexrazoxane Hydrochloride
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2018-09-19 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 2 |
What NCT03589729 shows while recruiting
NCT03589729 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 116-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (14% lower).
The record links to 7 conditions, with Acute Myeloid Leukemia appearing as the primary indexed condition, and to 5 interventions - of which Cladribine is the first listed.
NCT03589729 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT03589729 about?
NCT03589729 is a clinical study titled "Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers". This phase II trial studies how well dexrazoxane hydrochloride works in preventing heart-related side effects of chemotherapy in participants with blood cancers, such as acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia, and myeloproliferative neoplasms. Chemoprotective drug...
What is the current status of trial NCT03589729?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2018-09-19. Estimated completion is 2027-12-31.
What conditions does trial NCT03589729 study?
This clinical trial studies the following conditions: Acute Myeloid Leukemia, Myeloproliferative Neoplasm, High Risk Myelodysplastic Syndrome, Philadelphia Chromosome Positive, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive.
What interventions are being tested in trial NCT03589729?
The interventions under investigation include: Cladribine (DRUG), Gemtuzumab Ozogamicin (DRUG), Cytarabine (DRUG), Idarubicin (DRUG), Dexrazoxane Hydrochloride (DRUG).
Who is sponsoring clinical trial NCT03589729?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03589729 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03589729's enrollment target sits among peer trials
100 79th of 306 higher than 223 of 306 other Acute Myeloid Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Myeloid Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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