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ClinicalTrials.gov 11 recruiting now official registry

Multiple Sclerosis (Relapsing Remitting) clinical trials

11 of 30 indexed Multiple Sclerosis (Relapsing Remitting) trials are currently recruiting.

30 US clinical trials · 11 currently recruiting

Multiple Sclerosis (Relapsing Remitting) is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Shirley Ryan AbilityLab, running 4 of these trials.

The research picture

Multiple Sclerosis (Relapsing Remitting) has 30 registered US clinical trials, 11 of them open to new participants right now, about 37% of the total.

11
recruiting participants now
37%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
4
top sponsor: Shirley Ryan AbilityLab
Phase 13Phase 22Phase 36Phase 43

Active & Recent Trials

30 total, page 1 of 1

RECRUITING 1,000 participants

MS-ResearchBiomarkerS

Cedars-Sinai Medical Center

NCT05204459

RECRUITING Phase 3 194 participants

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

Celgene

NCT06408259

RECRUITING NA 100 participants

Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation

The University of Texas at Dallas

NCT05958381

RECRUITING 80 participants

Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis

Wayne State University

NCT04458688

RECRUITING Phase 1 74 participants

Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy

University of California, San Francisco

NCT05359653

RECRUITING NA 64 participants

Motor Learning of Fall Resistant Skills Through Slip and Trip Exposure in Multiple Sclerosis

Georgia State University

NCT06919900

RECRUITING 40 participants

Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis

Shirley Ryan AbilityLab

NCT06516458

RECRUITING NA 22 participants

Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS

Shirley Ryan AbilityLab

NCT06390930

RECRUITING NA 21 participants

Intermittent Hypoxia in Persons With Multiple Sclerosis

Shirley Ryan AbilityLab

NCT06276634

RECRUITING NA 14 participants

Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis

Cionic

NCT05964829

RECRUITING Phase 4 5 participants

Effects of Ocrelizumab Treatment on Immune Cells in Lymph Nodes in Multiple Sclerosis

University of California, San Francisco

NCT06495593

ACTIVE NOT RECRUITING 9,000 participants

A Post-Authorization, Long-term Study of Ozanimod Real-world Safety

Bristol-Myers Squibb

NCT05605782

ACTIVE NOT RECRUITING Phase 3 1,100 participants

Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis

Immunic

NCT05201638

ACTIVE NOT RECRUITING NA 900 participants

Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

Johns Hopkins University

NCT03500328

ACTIVE NOT RECRUITING Phase 4 800 participants

Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS

The Cleveland Clinic

NCT03535298

ACTIVE NOT RECRUITING NA 162 participants

Efficacy of Diet on Quality of Life in Multiple Sclerosis

Terry L. Wahls

NCT05007483

ACTIVE NOT RECRUITING Phase 3 152 participants

A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis

Biogen

NCT03958877

ACTIVE NOT RECRUITING NA 40 participants

The Synergistic Effects of AIH and FES in Persons With MS

Shirley Ryan AbilityLab

NCT06413602

COMPLETED Phase 3 1,016 participants

A Study to Asses Efficacy, Safety and Tolerability of Monthly Long-acting IM Injection of GA Depot in Subjects With RMS

Mapi Pharma

NCT04121221

COMPLETED Phase 3 608 participants

A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)

Genentech

NCT02637856

COMPLETED Phase 4 271 participants

An Efficacy and Safety Comparison Study of Two Marketed Drugs in Patients With Relapsing-remitting MS

Bayer

NCT00206648

COMPLETED 160 participants

Observational Registry of Acthar Gel for Participants With Multiple Sclerosis Relapse

Mallinckrodt

NCT02633033

COMPLETED 155 participants

A Study of Multiple Sclerosis Routine Clinical Practice: Impact on Adherence and Clinical Outcomes of Ofatumumab Treated Patients

Novartis Pharmaceuticals

NCT06897657

COMPLETED Phase 1 105 participants

Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis

Johns Hopkins University

NCT02988401

COMPLETED Phase 2 63 participants

Extension of Prior Study Evaluating Safety and Tolerability of Two Doses of Betaseron® to Treat Relapsing-remitting Multiple Sclerosis

Bayer

NCT00235989

COMPLETED NA 57 participants

Pharmacokinetics of Vitamin D in Multiple Sclerosis and in Health

Johns Hopkins University

NCT01667796

COMPLETED Phase 2 50 participants

Assessment of Clemastine Fumarate as a Remyelinating Agent in Multiple Sclerosis

University of California, San Francisco

NCT02040298

COMPLETED NA 35 participants

Light Therapy as Treatment for Fatigue in Multiple Sclerosis

Massachusetts General Hospital

NCT03060759

COMPLETED Phase 1 20 participants

Safety of RG2077 in Patients With Multiple Sclerosis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00076934

COMPLETED Phase 3 8 participants

ACTH for Fatigue in Multiple Sclerosis Patients

Providence Health & Services

NCT02315872

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 2
Phase 3 6
Phase 4 3

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis (Relapsing Remitting) Trial Landscape

30 indexed Multiple Sclerosis (Relapsing Remitting) studies · 11 recruiting (37%).

Phase mix: 9 late (III/IV) vs 5 early (I/II).

Top sponsor: Shirley Ryan AbilityLab (4 trials), 9 others listed. 30 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis (Relapsing Remitting)?

PlainTrial tracks 30 US clinical trials for Multiple Sclerosis (Relapsing Remitting), of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis (Relapsing Remitting)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.