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2026 data Public-data reference. official source

Metastatic Solid Tumors

Open-data reference.

21 US clinical trials · 15 currently recruiting

Active & Recent Trials

RECRUITING Phase 1 514 participants

A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification

BeiGene

NCT06585488

RECRUITING Phase 1 500 participants

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

Turning Point Therapeutics

NCT03093116

RECRUITING Phase 1 430 participants

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

Avenzo Therapeutics

NCT07038343

RECRUITING Phase 1 408 participants

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Incyte Corporation

NCT05836324

RECRUITING Phase 1 370 participants

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

Revolution Medicines

NCT07397338

RECRUITING Phase 1 355 participants

BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

Avenzo Therapeutics

NCT07193511

RECRUITING Phase 1 250 participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

Genentech

NCT06031441

RECRUITING Phase 2 200 participants

A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)

Daiichi Sankyo

NCT06660654

RECRUITING Phase 1 200 participants

A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors

Erasca

NCT06983743

RECRUITING Phase 1 200 participants

A Study of ERAS-4001 in Patients With Advanced or Metastatic Solid Tumors.

Erasca

NCT07021898

RECRUITING Phase 1 178 participants

Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)

Merck Sharp & Dohme

NCT05853367

RECRUITING Phase 1 75 participants

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

Turning Point Therapeutics

NCT04094610

RECRUITING Phase 1 70 participants

SLV-324 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT07108114

RECRUITING Phase 1 50 participants

Dose Escalation and Expansion Study Evaluating ODC-IL2 in Adult Patients With Advanced or Metastatic Solid Tumors

Trutino Biosciences

NCT06770764

RECRUITING NA 9 participants

The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.

New Phase

NCT07224464

ACTIVE NOT RECRUITING Phase 1 150 participants

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

AbbVie

NCT03893955

ACTIVE NOT RECRUITING Phase 1 95 participants

Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET

Turning Point Therapeutics

NCT03993873

ACTIVE NOT RECRUITING Phase 1 9 participants

A Study to Evaluate INCB177054 in Participants With Select Advanced or Metastatic Solid Tumors

Incyte Corporation

NCT06873789

COMPLETED Phase 4 25 participants

Rollover Study in Participants With Metastatic Solid Tumors Benefiting From Therapy With Sacituzumab Govitecan-hziy

Gilead Sciences

NCT04319198

COMPLETED Phase 1 23 participants

M1231 in Participants With Solid Tumors

EMD Serono Research & Development Institute

NCT04695847

COMPLETED Phase 1 17 participants

Safety, Tolerability, and Immunoregulatory Activity of Mogamulizumab (KW-0761) in Subjects With Advanced and/or Metastatic Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT02281409

Phase Distribution

PhaseTrial count
Early Phase 1 18
Phase 2 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Solid Tumors Trial Landscape

ClinicalTrials.gov lists 21 US studies indexed under Metastatic Solid Tumors, and 15 of those are currently open to recruitment — roughly 71% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Solid Tumors shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 19 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Solid Tumors is led by Turning Point Therapeutics with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 21 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Solid Tumors?

PlainTrial tracks 21 US clinical trials for Metastatic Solid Tumors, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Solid Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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