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RECRUITING Phase 1

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

NCT06031441 · View on ClinicalTrials.gov ↗

Study Summary

This is a first-in-human Phase I, open-label, dose-escalation and expansion study designed to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, pharmacodynamic, and preliminary anti-tumor activity of RO7566802 as a single agent and in combination with atezolizumab in participants with locally advanced, recurrent, or metastatic incurable solid tumor malignancies. Participants will be enrolled in 2 stages: dose escalation and expansion.

Interventions

  • DRUG Atezolizumab
  • DRUG RO7566802

Study Locations (18)

Other

  • National University Hospital — Singapore
  • National Cancer Centre — Singapore
  • Addenbrooke's Hospital — Cambridge
  • Leicester Royal Infirmary — Leicester
  • St Bartholomew's Hospital — London
  • Sarah Cannon Research Institute — London
  • Churchill Hospital — Oxford
  • The Royal Marsden hospital — Sutton

Alabama

  • University of Alabama at Birmingham (UAB) — Birmingham

Connecticut

  • Yale Cancer Center — New Haven

New York

  • Icahn School of Medicine at Mount Sinai (ISMMS) — New York

Ohio

  • The Ohio State University — Columbus

Pennsylvania

  • Magee-Woman's Hospital — Harrisburg

Tennessee

  • SCRI Oncology Partners — Nashville

New South Wales

  • St Vincent's Hospital Sydney — Darlinghurst

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2023-11-27
Est. Completion 2027-12-31
Phase Phase 1

Sponsor

Genentech

206 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06031441

The ClinicalTrials.gov registry entry for NCT06031441 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Metastatic Solid Tumors appearing as the primary indexed condition, and to 2 interventions — of which Atezolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06031441 reports 18 study locations spanning 11 distinct geographic areas — top geographies include Other, Alabama, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06031441 about?

NCT06031441 is a clinical study titled "A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors". This is a first-in-human Phase I, open-label, dose-escalation and expansion study designed to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, pharmacodynamic, and preliminary anti-tumor activity of RO7566802 as a single agent and in combination with atezolizumab in participants ...

What is the current status of trial NCT06031441?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 250 participants. The study started on 2023-11-27. Estimated completion is 2027-12-31.

What conditions does trial NCT06031441 study?

This clinical trial studies the following conditions: Metastatic Solid Tumors, Locally Advanced Solid Tumors, Recurrent Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06031441?

The interventions under investigation include: Atezolizumab (DRUG), RO7566802 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06031441?

This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06031441 being conducted?

This trial has 18 study locations across Alabama, Connecticut, New York, Ohio, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial