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Anal Cancer clinical trials
9 of 21 indexed Anal Cancer trials are currently recruiting.
21 US clinical trials · 9 currently recruiting
Anal Cancer is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 4 of these trials.
The research picture
Anal Cancer has 21 registered US clinical trials, 9 of them open to new participants right now, about 43% of the total.
- 9
- recruiting participants now
- 43%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 4
- top sponsor: National Cancer Institute (NCI)
Active & Recent Trials
21 total, page 1 of 1
Integrated Cancer Repository for Cancer Research
University of Nebraska
NCT02012699
Assessing THE GAY Male Experience With Anal Cancer Prevention Strategies
University of Minnesota
NCT05628194
Self-sampling to Optimize Anal Lesion Outcomes
Medical College of Wisconsin
NCT07192055
EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Case Comprehensive Cancer Center
NCT06263088
DESTINY-PANTUMOUR04
AstraZeneca
NCT07124000
Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
Dustin Deming
NCT06493019
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
Christian Hinrichs
NCT05686226
Detecting HPV DNA in Anal and Cervical Cancers
University of Chicago
NCT04857528
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Washington University School of Medicine
NCT06904365
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
Novartis Pharmaceuticals
NCT05544929
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
National Cancer Institute (NCI)
NCT04708470
Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies
National Cancer Institute (NCI)
NCT04287868
HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers
National Cancer Institute (NCI)
NCT04432597
REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation
University of Cincinnati
NCT05902533
Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions
AIDS Malignancy Consortium
NCT02135419
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Dan Zandberg
NCT04157985
Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer
Radiation Therapy Oncology Group
NCT00423293
Pembrolizumab in Metastatic Anal Cancer
Dana-Farber Cancer Institute
NCT02919969
Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer
Emory University
NCT01526486
SGN-00101 in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia
National Cancer Institute (NCI)
NCT00052897
Radiation Dosimetry Study Comparing 2 Different Patient Setups in Anal/Rectal Cancer Patients
The University of Texas Medical Branch, Galveston
NCT00693173
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 5 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Anal Cancer Trial Landscape
21 indexed Anal Cancer studies · 9 recruiting (43%).
Phase mix: 2 late (III/IV) vs 10 early (I/II).
Top sponsor: National Cancer Institute (NCI) (4 trials), 9 others listed. 21 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Anal Cancer?
PlainTrial tracks 21 US clinical trials for Anal Cancer, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Anal Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.