Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Anal Cancer: early-phase trial registry
9 of 21 indexed Anal Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #797 of 28,707 conditions by registered trial count.
21 US clinical trials · 9 currently recruiting · #797 of 28,707 conditions by registered trial count
Anal Cancer: 21 US clinical trials tracked, 9 recruiting.
Anal Cancer is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 4 of these trials.
Enrollment posture brief
Registry condition anal-cancer
OPEN 9 | RECR 43% | LATE 2 | EARLY 10 | RANK #797 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Acute Myelogenous Leukemia (AML) (43% recruiting · 7 trials)
Anal Cancer lists 9 open slots (43% of 21 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Anal Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Anal Cancer is recruiting above its size-band peers.
9 of 21 indexed trials (42.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Anal Cancer research.
National Cancer Institute (NCI) accounts for 4 of 21 trials (19%). 18 distinct sponsors appear on at least one study for this condition label.
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Most Anal Cancer trials plan to enrol fewer than 100 people.
Median target enrolment is 51 among the 20 trials that report a genuine target (sentinel values excluded). 13 of those (65%) plan for fewer than 100 participants.
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Anal Cancer research is mostly interventional.
15 interventional and 6 observational studies make up this index (71.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
21 total, page 1 of 1
Integrated Cancer Repository for Cancer Research
University of Nebraska
NCT02012699
Assessing THE GAY Male Experience With Anal Cancer Prevention Strategies
University of Minnesota
NCT05628194
Self-sampling to Optimize Anal Lesion Outcomes
Medical College of Wisconsin
NCT07192055
EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Case Comprehensive Cancer Center
NCT06263088
DESTINY-PANTUMOUR04
AstraZeneca
NCT07124000
Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
Dustin Deming
NCT06493019
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
Christian Hinrichs
NCT05686226
Detecting HPV DNA in Anal and Cervical Cancers
University of Chicago
NCT04857528
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Washington University School of Medicine
NCT06904365
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
Novartis Pharmaceuticals
NCT05544929
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
National Cancer Institute (NCI)
NCT04708470
Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies
National Cancer Institute (NCI)
NCT04287868
HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers
National Cancer Institute (NCI)
NCT04432597
REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation
University of Cincinnati
NCT05902533
Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions
AIDS Malignancy Consortium
NCT02135419
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Dan Zandberg
NCT04157985
Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer
Radiation Therapy Oncology Group
NCT00423293
Pembrolizumab in Metastatic Anal Cancer
Dana-Farber Cancer Institute
NCT02919969
Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer
Emory University
NCT01526486
SGN-00101 in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia
National Cancer Institute (NCI)
NCT00052897
Radiation Dosimetry Study Comparing 2 Different Patient Setups in Anal/Rectal Cancer Patients
The University of Texas Medical Branch, Galveston
NCT00693173
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 5 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Anal Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Anal Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Anal Cancer page
21 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 Anal Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Cancer Institute (NCI) sponsors the most Anal Cancer trials on record, review their full trial history before evaluating a specific study. See National Cancer Institute (NCI)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Anal Cancer condition card totals 21 registered trials; most-linked intervention M7824; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.